PRIMARY STRUCTURE AND LOCALIZATION OF A CONSERVED IMMUNOGENIC PLASMODIUM-FALCIPARUM GLUTAMATE RICH PROTEIN (GLURP) EXPRESSED IN BOTH THE PREERYTHROCYTIC AND ERYTHROCYTIC STAGES OF THE VERTEBRATE LIFE-CYCLE

被引：129

作者：

BORRE, MB

DZIEGIEL, M

HOGH, B

PETERSEN, E

RIENECK, K

RILEY, E

MEIS, JF

AIKAWA, M

NAKAMURA, K

HARADA, M

WIND, A

JAKOBSEN, PH

COWLAND, J

JEPSEN, S

AXELSEN, NH

VUUST, J

机构：

[1] MRC LABS, FAJARA, SENEGAMBIA

[2] CATHOLIC UNIV NIJMEGEN, INST MED MICROBIOL, NIJMEGEN, NETHERLANDS

[3] CASE WESTERN RESERVE UNIV, INST PATHOL, CLEVELAND, OH 44106 USA

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1991年 / 49卷 / 01期

关键词：

PLASMODIUM-FALCIPARUM; EXOANTIGEN; GLUTAMATE-RICH PROTEIN; CONSERVATION; REPEATED SEQUENCES; T-CELL AND B-CELL SITES;

D O I：

10.1016/0166-6851(91)90135-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A gene coding for a 220-kDa glutamate rich protein (GLURP), an exoantigen of Plasmodium falciparum, was isolated and its nucleotide sequence was determined. The deduced amino acid sequence contains 2 repeat regions. The sequence of one of these was shown to be conserved among geographically dispersed isolates, and a fusion protein containing that sequence was able to stimulate B- and T-cells. Antibodies against GLURP stained erythrocytic stages of the parasite as well as the hepatic stage as detected by electron microscopy.

引用

页码：119 / 132

页数：14

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