NEWER APPROACHES TO THE RADIOLABELING OF MONOCLONAL-ANTIBODIES BY USE OF METAL-CHELATES

被引：88

作者：

GANSOW, OA

机构：

[1] Chemistry Section, Radiation Oncology Branch, National Institutes of Health, Bethesda, MD 20892

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1991年 / 18卷 / 04期

关键词：

D O I：

10.1016/0883-2897(91)90063-Q

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Monoclonal antibodies (mAbs) radiolabeled by use of metal chelators are being investigated in the laboratory for use in clinical trials. In-111 is presently employed for diagnostic scintigraphy, but its applications are limited by substantive and persistant uptake of radiometal in the liver. Much current research is focused on performing cancer therapy with Y-90 and Bi-212 chelate-linked mAbs. This report chronicles the development and evaluation of chelating agents for In-111-radioimmunoimaging and Y-90- and Bi-212-radioimmunotherapy.

引用

页码：369 / 381

页数：13

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