DESTRUCTION OF THE LOCUS-CERULEUS DECREASES PHYSICAL SIGNS OF OPIATE WITHDRAWAL

被引：139

作者：

MALDONADO, R ^{[1
]}

KOOB, GF ^{[1
]}

机构：

[1] Scripps Res Inst, DEPT NEUROPHARMACOL, 10666 N TORREY PINES RD, LA JOLLA, CA 92037 USA

来源：

BRAIN RESEARCH | 1993年 / 605卷 / 01期

关键词：

MORPHINE DEPENDENCE; LOCUS CERULEUS; ELECTROLYTICAL LESION; METHYLNALOXONIUM; INTRACEREBROVENTRICULAR;

D O I：

10.1016/0006-8993(93)91364-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The purpose of the present study was to investigate the role of the locus coeruleus in the development of opiate dependence. Two groups of rats each were subjected to either a electrolytic lesion of the locus coeruleus or a sham lesion. All animals were implanted with an intracerebroventricular (i.c.v.) cannula, and made physically dependent by subcutaneous insertion of two 75-mg morphine (base) pellets. Abstinence was precipitated by i.cv. administration of methylnaloxonium (31-1,000 ng) 72 h after pellet implantation. Methylnaloxonium administered intracerebroventricularly induced a withdrawal syndrome characterized by the appearance of teeth chattering, mastication, rearing, wet dog shakes, jumping, piloerection, hyperactivity, ptosis and eye twitch. Withdrawal observed in the electrolytic lesion groups was less severe than in sham group. The presence of mastication, rearing, piloerection, hyperactivity, ptosis and eye twitch was significantly lower. These results support the hypothesis that the locus coeruleus has an important role in the expression of the physical signs of opiate dependence.

引用

页码：128 / 138

页数：11

共 43 条

[21]

KERR FWL, 1971, MAYO CLIN PROC, V46, P653

[22]

KIMES AS, 1989, J PHARMACOL EXP THER, V248, P538

[23] DESTRUCTION OF THE LOCUS COERULEUS OR THE DORSAL NE BUNDLE DOES NOT ALTER THE RELEASE OF PUNISHED RESPONDING BY ETHANOL AND CHLORDIAZEPOXIDE [J].

KOOB, GF ;

THATCHERBRITTON, K ;

BRITTON, DR ;

ROBERTS, DCS ;

BLOOM, FE .

PHYSIOLOGY & BEHAVIOR, 1984, 33 (03) :479-485

[24] CELLULAR AND MOLECULAR MECHANISMS OF DRUG-DEPENDENCE [J].

KOOB, GF ;

BLOOM, FE .

SCIENCE, 1988, 242 (4879) :715-723

[25] SITES OF ACTION OF MORPHINE INVOLVED IN DEVELOPMENT OF PHYSICAL-DEPENDENCE IN RATS .2. MORPHINE WITHDRAWAL PRECIPITATED BY APPLICATION OF MORPHINE ANTAGONISTS INTO RESTRICTED PARTS OF VENTRICULAR SYSTEM AND BY MICROINJECTION INTO VARIOUS BRAIN AREAS [J].

LASCHKA, E ;

TESCHEMACHER, H ;

MEHRAEIN, P ;

HERZ, A .

PSYCHOPHARMACOLOGIA, 1976, 46 (02) :141-147

[26] CLONIDINE REVERSES THE INCREASED NOREPINEPHRINE TURNOVER DURING MORPHINE WITHDRAWAL IN RATS [J].

LAVERTY, R ;

ROTH, RH .

BRAIN RESEARCH, 1980, 182 (02) :482-485

[27] HYPERSENSITIVITY TO NORADRENALINE IN CORTEX AFTER CHRONIC MORPHINE - RELEVANCE TO TOLERANCE AND DEPENDENCE [J].

LLORENS, C ;

MARTRES, MP ;

BAUDRY, M ;

SCHWARTZ, JC .

NATURE, 1978, 274 (5671) :603-605

[28] DIFFERENCES IN PHYSICAL-DEPENDENCE INDUCED BY SELECTIVE MU-OPIOID OR DELTA-OPIOID AGONISTS AND BY ENDOGENOUS ENKEPHALINS PROTECTED BY PEPTIDASE INHIBITORS [J].

MALDONADO, R ;

FEGER, J ;

FOURNIEZALUSKI, MC ;

ROQUES, BP .

BRAIN RESEARCH, 1990, 520 (1-2) :247-254

[29]

MALDONADO R, 1992, J PHARMACOL EXP THER, V261, P669

[30]

Paxinos G., 2007, RAT BRAIN STEROTAXIC

← 1 2 3 4 5 →