共 21 条
[21]
WOOD H, 1990, UNPUB
EXCITOTOXIN LESION OF NUCLEUS BASALIS CAUSES A SPECIFIC DECREASE IN G0 MESSENGER-RNA IN CEREBRAL-CORTEX - SENSITIVITY TO MK-801
被引：9
作者：
WOOD, H
DEBELLEROCHE, J
机构：
[1] Department of Biochemistry, Charing Cross and Westminster Medical School, London, W6 8RF, Fulham Palace Road
关键词：
Cerebral cortex;
G-protein;
Messenger RNA;
MK-801;
Nucleus basalis;
W-methyl-D-aspartate receptor;
D O I：
10.1016/0014-5793(90)81051-O
中图分类号：
Q5 [生物化学];
Q7 [分子生物学];
学科分类号：
071010 ;
081704 ;
摘要：
Lesions of the ascending cholinergic pathway from nucleus basalis are known to have profound effects on cortical function. In particular, a substantial potentiation of carbachol-stimulated polyphosphoinositide turnover is detected from 1 day after lesion and is maintained for several days before returning to normal by 1 month. In this study the effect of this lesion was investigated on levels of three G-protein α-subunit mRNAs. Excitotoxin lesion of the nucleus basalis caused a selective reduction in the levels of Goα mRNA in cerebral cortex ipsilateral to the lesion, G5α and Giα mRNA being unaffected. The maximal effect was obtained at 3 days after lesion where levels of Goα mRNA were decreased by 40% compared to sham-operated animals. Levels of Goα mRNA returned to normal values by 28 days. Treatment with MK-801 caused a significant attenuation of the decrease in Goα mRNA, indicating the involvement of NMDA receptors in this response. © 1990.
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页码：63 / 67
页数：5
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