SYNTHESIS AND RECEPTOR-BINDING AFFINITY OF 7-ALPHA-SUBSTITUTED AND 17-ALPHA-SUBSTITUTED 2-CHLOROESTRADIOL AND 4-CHLOROESTRADIOL DERIVATIVES

被引：15

作者：

ALI, H ^{[1
]}

VANLIER, JE ^{[1
]}

机构：

[1] UNIV SHERBROOKE,FAC MED,MRC,RADIAT SCI GRP,SHERBROOKE J1H 5N4,QUEBEC,CANADA

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1991年 / 10期

关键词：

D O I：

10.1039/p19910002485

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Methods for the selective syntheses of 2- and 4-chloroestradiol derivatives substituted at the 17-alpha- and 7-alpha-positions are described. The relative binding affinities for estrogen receptors of these estrogens are also reported, and potential structure-activity relationships are put forth.

引用

页码：2485 / 2491

页数：7

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