IRRADIATION INCREASES PROTEOLYSIS IN ERYTHROCYTE-GHOSTS - A SPIN LABEL STUDY

被引：8

作者：

BARTOSZ, G

SCHON, W

KRAFT, G

GARTNER, H

机构：

[1] GESAMTHSCH KASSEL,FACHBEREICH PHYS,W-3500 KASSEL,GERMANY

[2] GESELL SCHWERIONENFORSCH GMBH,W-6100 DARMSTADT,GERMANY

来源：

RADIATION AND ENVIRONMENTAL BIOPHYSICS | 1992年 / 31卷 / 02期

关键词：

D O I：

10.1007/BF01211209

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

X- and gamma-irradiation of human erythrocyte membranes (250-1000 Gy) was found to decrease the ratio of weakly to strongly immobilized signal height of membrane-bound maleimide spin label (Mal-6). Subsequent incubation of spin-labeled membranes at ambient temperature (21-degrees-C) induced a progressive increase in this ratio, faster for membranes irradiated with low doses which was hampered by protease inhibitors. These results demonstrate that ionizing radiation stimulates proteolysis of erythrocyte membrane proteins by membrane-associated proteases.

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页码：117 / 121

页数：5

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