MECHANISMS OF THE CYTOPATHIC ACTION OF ACTIN-ADP-RIBOSYLATING TOXINS

被引：81

作者：

AKTORIES, K ^{[1
]}

WEGNER, A ^{[1
]}

机构：

[1] RUHR UNIV BOCHUM,INST PHYSIOL CHEM,W-4630 BOCHUM,GERMANY

来源：

MOLECULAR MICROBIOLOGY | 1992年 / 6卷 / 20期

关键词：

D O I：

10.1111/j.1365-2958.1992.tb01749.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Clostridium botulinum C2 toxin, Clostridium perfringens iota toxin, and Clostridium spiroforme toxin ADP-ribosylate actin monomers. Toxin-induced ADP-ribosylation disturbs the cellular equilibrium between monomeric and polymeric actin and traps monomeric actin in its unpolymerized form, thereby depolymerizing actin filaments and destroying the microfilament network. Furthermore, the toxins ADP-ribosylate gel-solin actin complexes. These modifications may contribute to the cytopathic action of the toxins.

引用

页码：2905 / 2908

页数：4

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