ANTI-COMPLEMENT ACTIVITY OF OLEANOLIC ACID - AN INHIBITOR OF C-3-CONVERTASE OF THE CLASSICAL COMPLEMENT PATHWAY

被引：27

作者：

KAPIL, A

SHARMA, S

机构：

[1] Pharmacology Division, Regional Research Laboratory

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1994年 / 46卷 / 11期

关键词：

D O I：

10.1111/j.2042-7158.1994.tb05715.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Oleanolic acid is a naturally occurring compound, isolated from Luffa cylindrica, which inhibits the in-vitro immunohaemolysis of antibody-coated sheep erythrocytes by guinea-pig serum. In further experiments this reduced immunohaemolysis was found to be due to inhibition of the C-3-convertase of the classical complement pathway. The threshold concentration for inhibition of C-3-convertase was 100 mu g mL(-1). However, higher concentrations of oleanolic acid showed constant inhibitory effects on immunohaemolysis. Oleanolic acid also exhibited weak inhibitory effects on individual components of the complement system.

引用

页码：922 / 923

页数：2

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