EFFECT OF NILVADIPINE ON BALLOON CATHETERIZATION-INDUCED INTIMAL THICKENING OF THE CORONARY-ARTERY IN MINIATURE PIGS

被引:7
作者
ARAKAWA, H [1 ]
MUTOH, S [1 ]
HIROSUMI, J [1 ]
YAMAGUCHI, I [1 ]
机构
[1] FUJISAWA PHARMACEUT CO LTD,TSUKUBA RES LABS,BASIC RES GRP,2-3-5 TOKODAI,TSUKUBA,IBARAKI 30026,JAPAN
关键词
CALCIUM ANTAGONIST; CORONARY ARTERY; ATHEROSCLEROSIS; PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY;
D O I
10.1097/00005344-199211000-00007
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The effect of nilvadipine on balloon catheterization-induced intimal thickening of the coronary artery was examined in miniature pigs. A diffuse intimal thickening was observed in vehicle-treated controls 6 weeks after balloon catheterization. The histologic features of the intimal thickening resembled those of early atherosclerotic lesions and restenosis after percutaneous transluminal coronary angioplasty (PTCA). Nilvadipine given in a daily dose of 10 mg/kg (subcutaneously, s.c.) for 6 weeks significantly inhibited intimal thickening. The ratio of the cross-sectional area of the intima to the cross-sectional area of the media was significantly reduced by 62% in nilvadipine-treated animals. These results suggest that nilvadipine may prevent or exert beneficial effects on coronary arterial injuries such as atherosclerosis and restenosis after PTCA.
引用
收藏
页码:731 / 734
页数:4
相关论文
共 31 条
[1]   HISTAMINE-INDUCED CORONARY SPASM IN REGIONS OF INTIMAL THICKENING IN MINIATURE PIGS - ROLES OF SERUM-CHOLESTEROL AND SPONTANEOUS OR INDUCED INTIMAL THICKENING [J].
EGASHIRA, K ;
TOMOIKE, H ;
YAMAMOTO, Y ;
YAMADA, A ;
HAYASHI, Y ;
NAKAMURA, M .
CIRCULATION, 1986, 74 (04) :826-837
[2]  
FLECKENSTEIN A, 1983, 5TH INT AD S, P36
[3]   CARDIOVASCULAR EFFECTS OF FR34235, A NEW DIHYDROPYRIDINE SLOW CHANNEL BLOCKER, IN ISOLATED RABBIT MYOCARDIUM AND AORTA [J].
FURUTA, T ;
SHIBATA, S ;
KODAMA, I ;
YAMADA, K .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1983, 5 (05) :836-841
[4]   SUPPRESSION OF ATHEROGENESIS IN CHOLESTEROL-FED RABBIT TREATED WITH NIFEDIPINE [J].
HENRY, PD ;
BENTLEY, KI .
JOURNAL OF CLINICAL INVESTIGATION, 1981, 68 (05) :1366-1369
[5]   CALCIUM-ANTAGONISTS AS ANTIATHEROSCLEROTIC AGENTS [J].
HENRY, PD .
ARTERIOSCLEROSIS, 1990, 10 (06) :963-965
[6]  
HENRY PD, 1991, ARTERIOSCLEROSIS, V88, P109
[7]   INHIBITORY EFFECT OF CALCIUM-ANTAGONISTS ON BALLOON CATHETER-INDUCED ARTERIAL SMOOTH-MUSCLE CELL-PROLIFERATION AND LESION SIZE [J].
JACKSON, CL ;
BUSH, RC ;
BOWYER, DE .
ATHEROSCLEROSIS, 1988, 69 (2-3) :115-122
[8]   SELECTIVE HYPERCONTRACTION CAUSED BY ERGONOVINE IN THE CANINE CORONARY-ARTERY UNDER CONDITIONS OF INDUCED ATHEROSCLEROSIS [J].
KAWACHI, Y ;
TOMOIKE, H ;
MARUOKA, Y ;
KIKUCHI, Y ;
ARAKI, H ;
ISHII, Y ;
TANAKA, K ;
NAKAMURA, M .
CIRCULATION, 1984, 69 (02) :441-450
[9]   SUPPRESSION OF ATHEROGENESIS IN CHOLESTEROL-FED RABBITS TREATED WITH NILVADIPINE, A NEW VASOSELECTIVE CALCIUM ENTRY BLOCKER [J].
KOIBUCHI, Y ;
SAKAI, S ;
MIURA, S ;
ONO, T ;
SHIBAYAMA, F ;
OHTSUKA, M .
ATHEROSCLEROSIS, 1989, 79 (2-3) :147-155
[10]   ADVANCED CORONARY ATHEROSCLEROSIS IN SWINE PRODUCED BY COMBINATION OF BALLOON-CATHETER INJURY AND CHOLESTEROL FEEDING [J].
LEE, WM ;
LEE, KT .
EXPERIMENTAL AND MOLECULAR PATHOLOGY, 1975, 23 (03) :491-499