EFFECT OF NILVADIPINE ON BALLOON CATHETERIZATION-INDUCED INTIMAL THICKENING OF THE CORONARY-ARTERY IN MINIATURE PIGS

被引：7

作者：

ARAKAWA, H ^{[1
]}

MUTOH, S ^{[1
]}

HIROSUMI, J ^{[1
]}

YAMAGUCHI, I ^{[1
]}

机构：

[1] FUJISAWA PHARMACEUT CO LTD,TSUKUBA RES LABS,BASIC RES GRP,2-3-5 TOKODAI,TSUKUBA,IBARAKI 30026,JAPAN

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 1992年 / 20卷 / 05期

关键词：

CALCIUM ANTAGONIST; CORONARY ARTERY; ATHEROSCLEROSIS; PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY;

D O I：

10.1097/00005344-199211000-00007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of nilvadipine on balloon catheterization-induced intimal thickening of the coronary artery was examined in miniature pigs. A diffuse intimal thickening was observed in vehicle-treated controls 6 weeks after balloon catheterization. The histologic features of the intimal thickening resembled those of early atherosclerotic lesions and restenosis after percutaneous transluminal coronary angioplasty (PTCA). Nilvadipine given in a daily dose of 10 mg/kg (subcutaneously, s.c.) for 6 weeks significantly inhibited intimal thickening. The ratio of the cross-sectional area of the intima to the cross-sectional area of the media was significantly reduced by 62% in nilvadipine-treated animals. These results suggest that nilvadipine may prevent or exert beneficial effects on coronary arterial injuries such as atherosclerosis and restenosis after PTCA.

引用

页码：731 / 734

页数：4