ELEVATED SERUM LEVEL OF GLYCOLIPID SULFOTRANSFERASE IN PATIENTS WITH HEPATOCELLULAR-CARCINOMA

被引：8

作者：

GASA, S ^{[1
]}

CASL, MT ^{[1
]}

JIN, T ^{[1
]}

KAMIO, K ^{[1
]}

UEHARA, Y ^{[1
]}

MIYAZAKI, T ^{[1
]}

MAKITA, A ^{[1
]}

机构：

[1] HOKKAIDO UNIV,SCH MED,DEPT INTERNAL MED 3,SAPPORO,HOKKAIDO 060,JAPAN

来源：

CANCER LETTERS | 1991年 / 59卷 / 01期

关键词：

SULFOTRANSFERASE; SERUM; HEPATOCELLULAR CARCINOMA; GLYCOSPHINGOLIPID; SULFATIDE;

D O I：

10.1016/0304-3835(91)90130-A

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Activity of glycolipid sulfotransferase (cerebroside sulfotransferase) in serum was elevated in 21 (33%) of 63 patients with hepatocellular carcinoma (HCC, mean +/- S.E., 349 +/- 32 pmol/ml per h, n = 63, P < 0.001) compared to healthy subjects (172 +/- 12, n = 85). Ho significant elevation of the sulfotransferase level was observed in liver cirrhosis (219 +/- 28, n = 10) in which many of biochemical HCC markers increase concomitantly. The elevation of sulfotransferase was independent of the production of alpha-fetoprotein and of aminotransferase levels in HCC, providing complementary value for alpha-fetoprotein-negative HCC cases. However, the sulfotransferase levels (234 +/- 21, n = 32, P < 0.01) in sera from patients with renal cell carcinoma, in whose involved tissues the enzyme was demonstrated to increase markedly, were less than in HCC.

引用

页码：19 / 24

页数：6