RADIOIMMUNODETECTION OF HUMAN SMALL-CELL LUNG-CARCINOMA XENOGRAFTS IN THE NUDE RAT USING IN-111 LABELED MONOCLONAL-ANTIBODY MOC-31

被引：11

作者：

DEJONGE, MWA

KOSTERINK, JGW

BIN, YY

BULTE, JWM

KENGEN, RAM

PIERS, DA

THE, TH

DELEIJ, L

机构：

[1] UNIV HOSP GRONINGEN,DEPT NUCL MED,GRONINGEN,NETHERLANDS

[2] UNIV HOSP GRONINGEN,DEPT PHARM,GRONINGEN,NETHERLANDS

[3] CHINA JAPAN FRIENDSHIP HOSP,INST MED RES,DEPT BIOCHEM & IMMUNOL,BEIJING,PEOPLES R CHINA

来源：

EUROPEAN JOURNAL OF CANCER | 1993年 / 29A卷 / 13期

关键词：

D O I：

10.1016/0959-8049(93)90543-O

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The applicability of mouse monoclonal antibody MOC-31 for in vivo radioimmunodetection of human small cell lung cancer (SCLC) was investigated in a nude rat xenograft model. MOC-31 is reactive with a 38 kD pan-carcinoma membrane antigen. [In-111]DTPA-MOC-31 showed good in vivo immunolocalisation to xenografted SCLC cells, whereas antigen-related uptake was low in normal rat tissues and in a control antigen-negative, human-derived tumour. Non-antigen-related uptake in the liver could be blocked by pretreatment with irrelevant antibody. It is concluded that MOC-31 can be used for radioimmunodetection of SCLC in vivo and may be suitable as a targeting device in patients.

引用

页码：1885 / 1890

页数：6

共 31 条

[11]

DESHPANDE SV, 1990, J NUCL MED, V31, P218

[12]

EARY JF, 1990, J NUCL MED, V31, P1257

[13]

EPSTEIN AL, 1988, CANCER RES, V48, P5842

[14] ISOLATION OF PURE IGG1, IGG2A AND IGG2B IMMUNOGLOBULINS FROM MOUSE SERUM USING PROTEIN A-SEPHAROSE [J].

EY, PL ;

PROWSE, SJ ;

JENKIN, CR .

IMMUNOCHEMISTRY, 1978, 15 (07) :429-436

[15]

GOLDENBERG DM, 1988, ARCH PATHOL LAB MED, V112, P580

[16] EFFICIENT SELECTION OF HUMAN-TUMOR GROWTH-INHIBITING MONOCLONAL-ANTIBODIES [J].

HERLYN, D ;

HERLYN, M ;

ROSS, AH ;

ERNST, C ;

ATKINSON, B ;

KOPROWSKI, H .

JOURNAL OF IMMUNOLOGICAL METHODS, 1984, 73 (01) :157-167

[17] RADIOACTIVE LABELING OF ANTIBODY - A SIMPLE AND EFFICIENT METHOD [J].

HNATOWICH, DJ ;

LAYNE, WW ;

CHILDS, RL ;

LANTEIGNE, D ;

DAVIS, MA ;

GRIFFIN, TW ;

DOHERTY, PW .

SCIENCE, 1983, 220 (4597) :613-615

[18]

IANUZZI MC, 1986, AM REV RESPIR DIS, V134, P593

[19]

JAIN RK, 1990, CANCER RES, V50, pS814

[20]

JONES PL, 1990, CANCER RES, V50, pS852

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