金丝桃苷对低压低氧时大鼠认知功能损伤的改善作用附视频

被引：9

作者：

李锦松 ^{[1
]}

陈剑鸿 ^{[2
]}

孟民杰 ^{[1
]}

机构：

[1] 广东药学院生命科学与生物制药学院

[2] 第三军医大学大坪医院野战外科研究所药学部

来源：

局解手术学杂志 | 2015年 / 02期

关键词：

金丝桃苷; 低压低氧; 认知功能; 抗氧化活性;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

100806 [中药药理学];

摘要：

目的研究金丝桃苷(Hyperoside,Hyp)对低压低氧诱导大鼠认知功能损伤的预防作用。方法将大鼠分为空白组与用药组,空白组分为平原空白组和高原空白组,用药组分为平原Hyp低、中、高剂量组(10 mg/kg,20 mg/kg,40 mg/kg)和高原Hyp低、中、高剂量组(10 mg/kg,20 mg/kg,40 mg/kg)。高原各组置入模拟海拔6 100 m低压舱内7 d,平原各组置于常氧环境饲养,利用Morris水迷宫观察Hyp对大鼠认知功能损伤的影响;检测大鼠海马组织中的超氧化物歧化酶(superoxide dismutase,SOD)和过氧化氢酶(catalase,CAT)的活性、以及丙二醇(malondialdehyde,MDA)和还原型谷胱甘肽(reduced glutathione,GSH)的含量变化。结果低压低氧暴露后大鼠在目标象限的时间、距离和经过平台的次数均显著减少(P<0.05或P<0.01);Hyp治疗组显著削弱这一效应,相对低氧组,大鼠在目标象限的时间、距离以及经过平台的次数均显著提升(P<0.05或P<0.01)。Hyp治疗组海马组织中的SOD、CAT的活性和GSH含量均显著升高,MDA水平显著降低(P<0.05或P<0.01)。结论 Hyp对低压低氧引起的记忆损伤具有预防作用,其机制可能是通过上调SOD、CAT等蛋白的抗氧化活性,减轻低氧引起的氧化应激损伤。

引用

页码：181 / 184

页数：4

共 12 条

[1]

金丝桃苷对CCl4诱导大鼠急性肝损伤抗氧化应激研究 [J].

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陈剑鸿 ;

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[2]

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