金丝桃苷对CCl4诱导大鼠急性肝损伤抗氧化应激研究

被引：20

作者：

黄明春

陈剑鸿

胡小刚

夏培元

蔡永青

王强

机构：

[1] 第三军医大学西南医院药剂科

来源：

局解手术学杂志 | 2013年 / 22卷 / 06期

关键词：

金丝桃苷; CCl4; 急性肝损伤; 抗氧化活性;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

100806 [中药药理学];

摘要：

目的研究金丝桃苷(Hyp)对四氯化碳(CCl4)诱导大鼠急性肝损伤的治疗作用。方法采用大鼠CCl4急性肝损伤模型,观察Hyp对急性肝损伤大鼠肝脏组织病理学改变的影响;检测肝组织匀浆中超氧化物歧化酶(T-SOD)、谷胱甘肽(GSH)的活性及丙二醛(MDA)含量变化。结果 CCl4模型组大鼠肝组织HE染色病理检测结果见明显炎症变性坏死及纤维组织增生现象;Hyp高剂量60 mg/kg、中剂量30 mg/kg治疗组的肝组织病理改变明显改善;Hyp治疗组肝组织中T-SOD、GSH活性明显升高,MDA含量明显降低,并存在量效关系。结论 Hyp对CCl4引起的大鼠急性肝损伤有较好的治疗作用,其机制可能与其抗氧化活性有关。

引用

页码：588 / 590+593 +593

页数：4

共 11 条

[1]

Hepatoprotective evaluation of the total flavonoids extracted from flowers of Abelmoschus manihot (L.) Medic: In vitro and in vivo studies [J].

Ai, Guo ;

Liu, Qingchuan ;

Hua, Wei ;

Huang, Zhengming ;

Wang, Dewen .

JOURNAL OF ETHNOPHARMACOLOGY, 2013, 146 (03) :794-802

[2]

Hepatoprotective and antioxidant activity of pentagamavunon-0 against carbon tetrachloride-induced hepatic injury in rats [J].

Nurrochmad, Arief ;

Margono, Supardjan Amir ;

Sardjiman ;

Hakim, Arief Rahman ;

Ernawati ;

Kurniawati, Erna ;

Fatmawati, Erva .

ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE, 2013, 6 (06) :438-442

[3]

Carthamus red from Carthamus tinctorius L. exerts antioxidant and hepatoprotective effect against CCl4-induced liver damage in rats via the Nrf2 pathway [J].

Wu, Shuangchan ;

Yue, Yuan ;

Tian, Hui ;

Li, Zhike ;

Li, Xiaofei ;

He, Wei ;

Ding, Hong .

JOURNAL OF ETHNOPHARMACOLOGY, 2013, 148 (02) :570-578

[4]

Methyl helicterate protects against CCl4-induced liver injury in rats by inhibiting oxidative stress, NF-κB activation, Fas/FasL pathway and cytochrome P4502E1 level [J].

Lin, Xing ;

Huang, Renbin ;

Zhang, Shijun ;

Zheng, Li ;

Wei, Ling ;

He, Min ;

Zhou, Yan ;

Zhuo, Lang ;

Huang, Quanfang .

FOOD AND CHEMICAL TOXICOLOGY, 2012, 50 (10) :3413-3420

[5]

Xanthohumol prevents carbon tetrachloride-induced acute liver injury in rats [J].

Pinto, Carmen ;

Duque, Antonio L. ;

Rodriguez-Galdon, Beatriz ;

Cestero, Juan J. ;

Macias, Pedro .

FOOD AND CHEMICAL TOXICOLOGY, 2012, 50 (10) :3405-3412

[6]

Hyperoside attenuates hydrogen peroxide-induced L02 cell damage via MAPK-dependent Keap 1 –Nrf 2 –ARE signaling pathway.[J].Hai-Yan Xing;Yao Liu;Jian-Hong Chen;Feng-Jun Sun;Hui-Qing Shi;Pei-Yuan Xia.Biochemical and Biophysical Research Communications.2011, 4

[7]

金丝桃苷药理作用研究进展 [J].