线粒体凋亡通路的研究进展

被引：139

作者：

郑天胜 ^{[1
]}

李翔 ^{[2
]}

机构：

[1] 南京医科大学第一临床医学院

[2] 南京医科大学第一附属医院骨科

来源：

医学综述 | 2013年 / 19卷 / 18期

关键词：

线粒体; 凋亡; 蛋白;

D O I：

暂无

中图分类号：

R341 [];

学科分类号：

摘要：

长期以来,线粒体被认为是细胞存活的关键。然而,直到20世纪90年代中期,线粒体在细胞程序性死亡中所起的重要作用才被人们所认知。线粒体凋亡通路与线粒体相关的一些重要蛋白,如促凋亡因子、细胞色素C、凋亡诱导因子(AIF)、线粒体衍生的第二种半胱天冬酶激活剂(Smac)、高温应激蛋白A2(HtrA2)、核酸内切酶G等在细胞凋亡过程中共同发挥着调控作用。该文主要就线粒体凋亡通路在哺乳动物细胞中所起作用的研究进展予以综述。

引用

页码：3282 / 3285

页数：4

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