脑缺血的基因表达和基因治疗

被引:8
作者
曾现伟
沈建康
孙青芳
卞留贯
机构
[1] 上海第二医科大学附属瑞金医院神经外科
关键词
脑缺血; 基因表达; 基因治疗;
D O I
暂无
中图分类号
R743.3 [急性脑血管疾病(中风)];
学科分类号
100204 [神经病学];
摘要
卒中后,在梗死区周边存在一可逆的半暗带,利用神经保护因子或通过改变半暗带基因表达可保护半暗带,阻止脑组织缺血性损伤的发生和发展。文章对脑缺血基因治疗的原理、基因表达、实验方法和治疗等进行了综述。
引用
收藏
页码:283 / 286
页数:4
相关论文
共 9 条
[1]
Gene therapy for treatment of cerebral ischemia using defective herpes simplex viral vectors [J].
Yenari, MA ;
Dumas, TC ;
Sapolsky, RM ;
Steinberg, GK .
NEUROLOGICAL RESEARCH, 2001, 23 (05) :543-552
[2]
Adenovirus-mediated GDNF and CNTF pretreatment protects against striatal injury following transient middle cerebral artery occlusion in mice [J].
Hermann, DM ;
Kilic, E ;
Kügler, S ;
Isenmann, S ;
Bähr, M .
NEUROBIOLOGY OF DISEASE, 2001, 8 (04) :655-666
[3]
trkB-receptor activation contributes to the kainate-induced increase in BDNF mRNA synthesis [J].
Saarelainen, T ;
Vaittinen, S ;
Castrén, E .
CELLULAR AND MOLECULAR NEUROBIOLOGY, 2001, 21 (04) :429-435
[4]
Neurotrophic effect of basic fibroblast growth factor is mediated by the p42/p44 mitogen-activated protein kinase cascade in cultured rat cortical neurons [J].
Abe, K ;
Saito, H .
DEVELOPMENTAL BRAIN RESEARCH, 2000, 122 (01) :81-85
[5]
Brain-derived neurotrophic factor improves long-term potentiation and cognitive functions after transient forebrain ischemia in the rat [J].
Kiprianova, I ;
Sandkühler, J ;
Schwab, S ;
Hoyer, S ;
Spranger, M .
EXPERIMENTAL NEUROLOGY, 1999, 159 (02) :511-519
[6]
Role of plasminogen system components in focal cerebral ischemic infarction - A gene targeting and gene transfer study in mice [J].
Nagai, N ;
De Mol, M ;
Lijnen, HR ;
Carmeliet, P ;
Collen, D .
CIRCULATION, 1999, 99 (18) :2440-2444
[7]
Ischemic penumbra: The therapeutic window.[J].Antoine M. Hakim.Neurology.1998, 3 Su
[8]
Herpes simplex viral vectors expressing Bcl-2 are neuroprotective when delivered after a stroke [J].
Lawrence, MS ;
McLaughlin, JR ;
Sun, GH ;
Ho, DY ;
McIntosh, L ;
Kunis, DM ;
Sapolsky, RM ;
Steinberg, GK .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1997, 17 (07) :740-744
[9]
Intraventricular brain-derived neurotrophic factor reduces infarct size after focal cerebral ischemia in rats [J].
Schabitz, WR ;
Schwab, S ;
Spranger, M ;
Hacke, W .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1997, 17 (05) :500-506