氧化修饰对转录因子活性的调节

被引：2

作者：

桑晶

易静

机构：

[1] 上海交通大学医学院细胞生物学教研室

来源：

细胞生物学杂志 | 2009年 / 31卷 / 02期

关键词：

活性氧; 氧化还原; 氧化修饰; 转录因子;

D O I：

暂无

中图分类号：

Q343 [细胞遗传学];

学科分类号：

摘要：

基因的表达同时受到生理信号和环境刺激的调节。近年来,活性氧被认为是多种生长因子和细胞因子信号通路中的一种第二信使,同时其也产生在细胞损伤应激过程中。活性氧对转录因子的半胱氨酸位点的氧化还原状态有重要的决定作用,其主要影响转录因子二聚体构象的形成、与DNA结合的关键半胱氨酸位点的氧化还原状态、锌指等蛋白质构象的形成。关于氧化还原环境对控制增殖、分化、凋亡功能的转录因子OxyR、Yap-1、AP1、NF-κB、p53、Sp1、USF、HIF-1、C/EBP等的调节,已有大量研究提示氧化还原调节是一种关键的基因表达的调节方式。本文总结了氧化修饰对转录因子发挥调节作用的一般原理和若干典型例子。

引用

页码：191 / 197

页数：7

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