秦皮乙素及其衍生物的合成与药理学研究进展

被引：27

作者：

梁承远

张诗韵

毛跟年

宋慧慧

丁顺军

王兰

陈雪峰

机构：

[1] 陕西科技大学食品与生物工程学院

来源：

陕西科技大学学报(自然科学版) | 2015年 / 33卷 / 02期

关键词：

秦皮乙素; 香豆素; 合成; 衍生物; 药理活性;

D O I：

暂无

中图分类号：

R284 [中药化学]; R285 [中药药理学];

学科分类号：

100804 [中药化学]; 100806 [中药药理学];

摘要：

秦皮乙素是陕西道地药材秦皮的主要有效成分,化学名为6,7-二羟基香豆素,俗称七叶亭.秦皮乙素因其独特的结构及理化性质正日益引起科研人员的浓厚兴趣.科学家已研究发现秦皮乙素具有良好的抗肿瘤、抗炎及抗菌活性,显示了其广阔的应用前景.本文综述了近年来国内外学者对秦皮乙素及其合成与药理研究成果,以及近十年来秦皮乙素衍生物的合成与生物活性研究成果,包括抗溶组织梭菌胶原酶(ChC),灭杀白蚁,以及显著的抗大肠杆菌与抗念珠菌活性等.随着各种结构新颖的秦皮乙素衍生物不断地被合成报道,其生物活性与作用机制逐步被阐明,陕西道地药材秦皮及其主要成分秦皮乙素的开发与临床应用前景将会变得更加广阔.

引用

页码：126 / 133

页数：8

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