诱导性多潜能干细胞(iPS)的研究现状和展望

被引：5

作者：

陈凌懿

刘林

机构：

[1] 南开大学生命科学学院,生物活性材料教育部重点实验室

来源：

中国科学(C辑:生命科学) | 2009年 / 39卷 / 07期

关键词：

诱导多潜能性干细胞; iPS细胞; 体细胞重编程; 发育多潜能性;

D O I：

暂无

中图分类号：

Q813 [细胞工程];

学科分类号：

0836 ; 090102 ;

摘要：

诱导多潜能性干细胞(induced pluripotent stem cells,iPS细胞)是通过在分化的体细胞中表达特定的几个转录因子,以诱导体细胞的重编程而获得的可不断自我更新(self-renewal)且具有多向分化潜能的细胞.由于iPS既避免免疫排斥,又不涉及伦理道德问题,因此具有广泛且重要的临床应用价值.自从2006年Takahashi和Yamanaka报道成功地建立小鼠的iPS细胞以来,全世界众多实验室开始了iPS细胞研究,并取得了巨大进展.本文回顾过去几年内在iPS细胞研究领域中的新发现,包括建立iPS细胞的方法、iPS细胞形成的分子机制和iPS细胞的应用,并探讨该领域中急需解决的问题和发展前景.

引用

收藏

页码：621 / 635

页数：15

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