Pyroptosis in Skeleton Diseases: A Potential Therapeutic Target Based on Inflammatory Cell Death

被引：3

作者：

Wu, Qian ^{[1
]}

Du, Jiacheng ^{[1
]}

Bae, Eun Ju ^{[2
]}

Choi, Yunjung ^{[3
,4
]}

机构：

[1] Jeonbuk Natl Univ, Med Sch, Dept Biochem & Mol Biol, Jeonju 54896, South Korea

[2] Jeonbuk Natl Univ, Sch Pharm, Jeonju 54896, South Korea

[3] Jeonbuk Natl Univ, Med Sch, Dept Internal Med, Div Rheumatol, Jeonju 54896, South Korea

[4] Jeonbuk Natl Univ, Jeonbuk Natl Univ Hosp, Res Inst Clin Med, Biomed Res Inst, Jeonju 54907, South Korea

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 16期

基金：

新加坡国家研究基金会;

关键词：

pyroptosis; inflammation; skeleton diseases; treatment; cell death; INTERVERTEBRAL DISC DEGENERATION; SPINAL-CORD-INJURY; NLRP3; INFLAMMASOME; GASDERMIN-D; RHEUMATOID-ARTHRITIS; PROPIONIBACTERIUM-ACNES; METFORMIN PROTECTS; CASPASE ACTIVATION; AIM2; PORE FORMATION;

D O I：

10.3390/ijms25169068

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Skeletal disorders, including fractures, osteoporosis, osteoarthritis, rheumatoid arthritis, and spinal degenerative conditions, along with associated spinal cord injuries, significantly impair daily life and impose a substantial burden. Many of these conditions are notably linked to inflammation, with some classified as inflammatory diseases. Pyroptosis, a newly recognized form of inflammatory cell death, is primarily triggered by inflammasomes and executed by caspases, leading to inflammation and cell death through gasdermin proteins. Emerging research underscores the pivotal role of pyroptosis in skeletal disorders. This review explores the pyroptosis signaling pathways and their involvement in skeletal diseases, the modulation of pyroptosis by other signals in these conditions, and the current evidence supporting the therapeutic potential of targeting pyroptosis in treating skeletal disorders, aiming to offer novel insights for their management.

引用

页数：25

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