Tissue-specific functions of MSCs are linked to homeostatic muscle maintenance and alter with aging

被引：3

作者：

Kurosawa, Tamaki ^{[1
]}

Ikemoto-Uezumi, Madoka ^{[2
]}

Yoshimoto, Yuki ^{[3
]}

Minato, Keitaro ^{[4
]}

Kaji, Noriyuki ^{[5
]}

Chaen, Takashi ^{[1
]}

Hase, Eiji ^{[6
]}

Minamikawa, Takeo ^{[6
]}

Yasui, Takeshi ^{[7
]}

Horiguchi, Kazuhide ^{[8
]}

Iino, Satoshi ^{[9
]}

Hori, Masatoshi ^{[1
]}

Uezumi, Akiyoshi ^{[2
]}

机构：

[1] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Vet Med Sci, Lab Vet Pharmacol, Bunkyo Ku, Tokyo 1138657, Japan

[2] Kyushu Univ, Med Inst Bioregulat, Med Res Ctr High Depth Omics, Div Cell Heterogene, Fukuoka 812858, Japan

[3] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Mol Craniofacial Embryol & Oral Histol, Bunkyo Ku, Tokyo, Japan

[4] Niigata Univ, Grad Sch Med & Dent Sci, Dept Regenerat & Transplant Med, Div Orthoped Surg, Niigata, Japan

[5] Azabu Univ, Sch Vet Med, Lab Vet Pharmacol, Sagamihara, Kanagawa, Japan

[6] Tokushima Univ, Inst PostLED Photon, Div Interdisciplinary Res Med & Photon, Tokushima, Japan

[7] Tokushima Univ, Inst PostLED Photon, Div Next Generat Photon, Tokushima, Japan

[8] Int Univ Hlth & Welf, Sch Hlth Sci Odawara, Odawara, Kanagawa, Japan

[9] Univ Fukui, Fac Med Sci, Dept Anat, Div Med, Fukui, Japan

来源：

AGING CELL | 2024年 / 23卷 / 11期

基金：

日本学术振兴会; 日本科学技术振兴机构;

关键词：

heterogeneity; keratocan; mesenchymal stromal cells; platelet-derived growth factor receptor-alpha; sarcopenia; LEUCINE-RICH PROTEOGLYCANS; IN-VIVO; MESENCHYMAL PROGENITOR; FORCE TRANSMISSION; CELLS; DISTINCT; SARCOPENIA;

D O I：

10.1111/acel.14299

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Mesenchymal stromal cells (MSCs), also known as fibro-adipogenic progenitors, play a critical role in muscle maintenance and sarcopenia development. Although analogous MSCs are present in various tissues, recent single-cell RNA-seq studies have revealed the inter-tissue heterogeneity of MSCs. However, the functional significance of MSC heterogeneity and its role in aging remain unclear. Here, we investigated the properties of MSCs and their age-related changes in seven mouse tissues through histological, cell culture, and genetic examinations. The tissue of origin had a greater impact on the MSC transcriptome than aging. By first analyzing age-related changes, we found that Kera is exclusively expressed in muscle MSCs and significantly down-regulated by aging. Kera knockout mice recapitulated some sarcopenic phenotypes including reduced muscle mass and specific force, revealing the functional importance of Kera in the maintenance of muscle youth. These results suggest that MSCs have tissue-specific supportive functions and that deterioration in these functions may trigger tissue aging.

引用

页数：17

共 45 条

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