Regulation of endocytic traffic by Rho GTPases

被引：49

作者：

Qualmann, Britta ^{[1
]}

Mellor, Harry ^{[2
]}

机构：

[1] Dept. of Neurochem./Molec. Biology, Leibniz Institute for Neurobiology

[2] Mammalian Cell Biology Laboratory, Department of Biochemistry, University of Bristol

来源：

Biochemical Journal | 2003年 / 371卷 / 02期

关键词：

Actin; Endocytosis; Migration; Phagocytosis; Pinocytosis;

D O I：

10.1042/BJ20030139

中图分类号：

学科分类号：

摘要：

The members of the Rho subfamily of small GTPases are key regulators of the actin cytoskeleton. However, recent studies have provided evidence for multiple additional roles for these signalling proteins in controlling endocytic traffic. Here we review our current understanding of Rho GTPase action within the endocytic pathway and examine the potential points of convergence with the more established, actin-based functions of these signalling proteins.

引用

页码：233 / 241

页数：8

共 116 条

[71]

Murphy C., Saffrich R., Olivo-Marin J.C., Giner A., Ansorge W., Fotsis T., Zerial M., Dual function of rhoD in vesicular movement and cell motility, Eur. J. Cell Biol., 80, pp. 391-398, (2001)

[72]

Gasman S., Kalaidzidis Y., Zerial M., RhoD regulates endosome dynamics through Diaphanous-related formin and Src tyrosine kinase, Nat. Cell Biol., (2003)

[73]

Chang F., Peter M., Cell biology. Formins set the record straight, Science, 297, pp. 531-532, (2002)

[74]

Palazzo A.F., Cook T.A., Alberts A.S., Gundersen G.G., mDia mediates Rho-regulated formation and orientation of stable microtubules, Nat. Cell Biol., 3, pp. 723-729, (2001)

[75]

Tominaga T., Sahai E., Chardin P., McCormick F., Courtneidge S.A., Alberts A.S., Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling, Mol. Cell, 5, pp. 13-25, (2000)

[76]

Barois N., Forquet F., Davoust J., Actin microfilaments control the MHC class II antigen presentation pathway in B cells, J. Cell Sci., 111, pp. 1791-1800, (1998)

[77]

Van Deurs B., Holm P.K., Kayser L., Sandvig K., Delivery to lysosomes in the human carcinoma cell line HEp-2 involves an actin filament-facilitated fusion between mature endosomes and preexisting lysosomes, Eur. J. Cell Biol., 66, pp. 309-323, (1995)

[78]

Luzio J.P., Mullock B.M., Pryor P.R., Lindsay M.R., James D.E., Piper R.C., Relationship between endosomes and lysosomes, Biochem. Soc. Trans., 29, pp. 476-480, (2001)

[79]

Muller O., Johnson D.I., Mayer A., Cdc42p functions at the docking stage of yeast vacuole membrane fusion, EMBO J., 20, pp. 5657-5665, (2001)

[80]

Eitzen G., Thorngren N., Wickner W., Rho1p and Cdc42p act after Ypt7p to regulate vacuole docking, EMBO J., 20, pp. 5650-5656, (2001)

← 3 4 5 6 7 8 9 10 11 12 →