Application of proteomics in biotechnology - Microbial proteomics

被引：16

作者：

Proteomics Core, COBRE Center for Cancer Research Development, Rhode Island Hospital, 1 Hoppin Streetst-4, Providence, RI 02904, United States ^{[1
]}

不详 ^{[2
]}

不详 ^{[3
]}

机构：

[1] Proteomics Core, COBRE Center for Cancer Research Development, Rhode Island Hospital, Providence, RI 02904

[2] Brown University Medical School, Providence, RI

[3] J. J. Strossmayer University of Osijek, Department of Chemistry, Osijek

来源：

Biotechnol. J. | 2008年 / 4卷 / 496-509期

关键词：

Genomics; Microbial proteomics; Process development;

D O I：

10.1002/biot.200700234

中图分类号：

学科分类号：

摘要：

The genomes of most economically important microbial cells are already sequenced and proteomic technologies can be applied during various process development steps, starting with the selection and optimization of the functions of the industrial strains, application of the knowledge of cell function in response to the changes of production parameters, validation of the downstream processing, and thorough characterization of the final product. Unfortunately, there are only a few direct examples in the literature that present the optimization of the production process based on proteomics. In this review, we discuss the potential of this technology for the design of future bioprocesses and for optimization of existing ones. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：496 / 509

页数：13

共 175 条

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