Second pregnancy in China 5 years after ovarian tissue transplantation to prevent iatrogenic POI

被引：0

作者：

Ruan, Xiangyan ^{[1
,2
,3
]}

Du, Juan ^{[1
]}

Jin, Fengyu ^{[1
]}

Gu, Muqing ^{[1
]}

Cheng, Jiaojiao ^{[1
]}

Li, Yanglu ^{[1
]}

Dai, Yinmei ^{[1
]}

Korell, Matthias ^{[4
]}

Montag, Markus ^{[5
]}

Liebenthron, Jana ^{[6
]}

Mueck, Alfred O. ^{[1
,2
,3
]}

机构：

[1] Capital Med Univ, Beijing Obstet & Gynecol Hosp, Beijing Maternal & Child Hlth Care Hosp, Dept Gynecol Endocrinol, 251,Yaojiayuan Rd, Beijing 100026, Peoples R China

[2] Univ Tubingen, Univ Womens Hosp, Tubingen, Germany

[3] Univ Tubingen, Res Ctr Womens Hlth, Dept Womens Hlth, Tubingen, Germany

[4] Johanna Etienne Hosp, Dept Obstet & Gynecol, Neuss, Germany

[5] Ilabcomm GmbH, Augustin, Germany

[6] Univ Womens Hosp Dusseldorf, Univ Cryobank Assisted Reprod Med & Fertil Protect, UniCareD, Dusseldorf, Germany

来源：

CLIMACTERIC | 2025年 / 28卷 / 02期

基金：

北京市自然科学基金;

关键词：

Ovarian tissue cryopreservation; ovarian tissue transplantation; aplastic anemia; live birth; China; premature ovarian insufficiency; FERTILITY PRESERVATION; WOMEN; AXIS;

D O I：

10.1080/13697137.2025.2471062

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

ObjectiveThis article reports the second live birth in China after frozen-thawed ovarian tissue transplantation to prevent iatrogenic premature ovarian insufficiency (POI).MethodA patient with aplastic anemia received ovarian tissue cryopreservation before hematopoietic stem cell transplantation, and four ovarian cortex strips were thawed and transplanted into her peritoneal pocket 18 months later.ResultsPregnancy occurred spontaneously 5 years after grafting, and a healthy girl was born at 39 weeks of gestation. Until now, the child has developed normally without any major diseases.ConclusionOvarian tissue cryopreservation and transplantation (OTCT) can be assessed as a successful method especially to prevent iatrogenic POI. In our cryobank for OTCT, which is the first official one in China, intensive research to improve this method has been performed, and we propose after our success for the second pregnancy in China to include this method in the official guidelines for prevention and treatment of (especially iatrogenic) POI.

引用

页码：212 / 216

页数：5

共 25 条

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