NUCLEAR SIZE AND CHROMATIN CONCENTRATION IN TRANSITIONAL CELL-CARCINOMA OF HUMAN URINARY-BLADDER

被引：33

作者：

FOSSA, SD

KAALHUS, O

机构：

[1] NORWEGIAN RADIUM HOSP, DEPT GEN, UROL SECT, OSLO, NORWAY

[2] NORSK HYDROS INST CANC RES, DEPT TISSUE CULTURE, OSLO, NORWAY

[3] NORSK HYDROS INST CANC RES, DEPT BIOPHYS, OSLO, NORWAY

来源：

BEITRAGE ZUR PATHOLOGIE | 1976年 / 157卷 / 02期

关键词：

D O I：

10.1016/S0005-8165(76)80098-4

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Feulgen stained nuclei from 25 specimens from transitional cell carcinoma of the human bladder were examined by cytophotometric scanning. The mean values of nuclear area, DNA content and chromatin concentration after scanning of 100 nuclei/specimen were compared with those from a control group consisting of 10 specimens of normal transitional cell epithelium. Within the same ploidy class the more differentiated carcinoma cells showed nuclear enlargement and decrease of mean chromatin concentration. Undifferentiated tumors could have the same or higher mean chromatin concentration as the control group owing to the many high polyploid nuclei. Undifferentiated tumors contained numerous giant nuclei, whereas these were rare in well differentiated carcinoma. When allowances were made for variations due to fixation, staining measurement of the nuclear area could serve as a means of differentiating between normal and cancer nuclei with a high degree of statistic probability. The question whether nuclear enlargement and decreased chromatin concentration represent physiological changes or are entirely or partly the result of chemical carcinogenesis is discussed.

引用

页码：109 / 125

页数：17

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