NEW IMMUNOGLOBULIN VARIANT - GAMMA-3 HEAVY-CHAIN DISEASE PROTEIN CHI

被引：19

作者：

FRANGIONE, B ^{[1
]}

机构：

[1] NYU, MED CTR, DEPT PATHOL, IRVINGTON HOUSE INST, NEW YORK, NY 10016 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1976年 / 73卷 / 05期

关键词：

D O I：

10.1073/pnas.73.5.1552

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Protein CHI is a defective human .gamma.3 H chain immunoglobulin with a deletion encompassing a portion of the variable and constant regions. Joining of the 2 pieces takes place at the beginning of an extra fragment (Fh) in the constant region where repetitive sequences are found, apparently as the result of gene duplications and/or unequal crossover between .gamma. genes. A 45 nucleotide fragment is probably the repetitive unit coding for the extra fragment.

引用

页码：1552 / 1555

页数：4

共 31 条

[1]

ADLERSBERG JB, 1975, P NATL ACAD SCI USA, V72, P723, DOI 10.1073/pnas.72.2.723

[2] GEL-FILTRATION BEHAVIOUR OF PROTEINS RELATED TO THEIR MOLECULAR WEIGHTS OVER A WIDE RANGE [J].

ANDREWS, P .

BIOCHEMICAL JOURNAL, 1965, 96 (03) :595-&

[3]

BAKER AS, IN PRESS

[4] PURIFICATION AND SOME CHARACTERISTICS OF 5S DNA FROM XENOPUS-LAEVIS [J].

BROWN, RD ;

WENSINK, PC ;

JORDAN, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1971, 68 (12) :3175-&

[5] GENETIC MOLECULAR AND CELLULAR BASIS OF ANTIBODY FORMATION - SOME FACTS AND A UNIFYING HYPOTHESIS [J].

DREYER, WJ ;

GRAY, WR ;

HOOD, L .

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1967, 32 :353-&

[6] COVALENT STRUCTURE OF AN ENTIRE GAMMAG IMMUNOGLOBULIN MOLECULE [J].

EDELMAN, GM ;

CUNNINGHAM, BA ;

GALL, WE ;

GOTTLIEB, PD ;

RUTISHAUSER, U ;

WAXDAL, MJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1969, 63 (01) :78-+

[7] A PROTEIN SEQUENATOR [J].

EDMAN, P ;

BEGG, G .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1967, 1 (01) :80-&

[8] HINGE-REGION DELETION LOCALIZED IN IGG1-GLOBULIN MCG [J].

FETT, JW ;

DEUTSCH, HF ;

SMITHIES, O .

IMMUNOCHEMISTRY, 1973, 10 (02) :115-118

[9] PARTIAL DUPLICATION IN HINGE REGION OF IGA1 MYELOMA PROTEINS [J].

FRANGION.B ;

WOLFENST.C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1972, 69 (12) :3673-3676

[10]

FRANGIONE B., 1968, J MOL BIOL, V33, P893, DOI 10.1016/0022-2836(68)90326-4

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