NEW IMMUNOGLOBULIN VARIANT - GAMMA-3 HEAVY-CHAIN DISEASE PROTEIN CHI

被引：19

作者：

FRANGIONE, B ^{[1
]}

机构：

[1] NYU, MED CTR, DEPT PATHOL, IRVINGTON HOUSE INST, NEW YORK, NY 10016 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1976年 / 73卷 / 05期

关键词：

D O I：

10.1073/pnas.73.5.1552

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Protein CHI is a defective human .gamma.3 H chain immunoglobulin with a deletion encompassing a portion of the variable and constant regions. Joining of the 2 pieces takes place at the beginning of an extra fragment (Fh) in the constant region where repetitive sequences are found, apparently as the result of gene duplications and/or unequal crossover between .gamma. genes. A 45 nucleotide fragment is probably the repetitive unit coding for the extra fragment.

引用

页码：1552 / 1555

页数：4

共 31 条

[21] HINGE REGION OF IGG3, AN EXTENDED PART OF MOLECULE [J].

MICHAELSEN, TE ;

NATVIG, JB .

FEBS LETTERS, 1972, 28 (01) :121-+

[22]

MICHAELSEN TE, 1974, J BIOL CHEM, V249, P2778

[23] ISOLATION OF A FRAGMENT FH, CORRESPONDING TO HINGE REGION OF HUMAN IGG3 [J].

MICHAELSEN, TE ;

NATVIG, JB ;

SLETTEN, K .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1974, 3 (04) :491-498

[24]

MILSTEIN C, 1974, 2ND PROG IMM INT C I, V1, P157

[25] CLINICAL + IMMUNOCHEMICAL STUDIES OF 4 CASES OF HEAVY (HGAMMA2) CHAIN DISEASE [J].

OSSERMAN, EF ;

TAKATSUKI, K .

AMERICAN JOURNAL OF MEDICINE, 1964, 37 (03) :351-&

[26]

OUCHTERLONY O, 1953, ACTA PATHOL MIC SC, V32, P231

[27] N- AND C-TERMINAL AMINO ACID SEQUENCES OF HEAVY CHAIN FROM A PATHOLOGICAL HUMAN IMMUNOGLOBULIN IGG [J].

PRESS, EM ;

PIGGOT, PJ ;

PORTER, RR .

BIOCHEMICAL JOURNAL, 1966, 99 (02) :356-+

[28]

SALUK PH, 1971, J IMMUNOL, V107, P298

[29] PATHWAYS THROUGH NETWORKS OF BRANCHED DNA [J].

SMITHIES, O .

SCIENCE, 1970, 169 (3948) :882-&

[30]

WEBER K, 1969, J BIOL CHEM, V244, P4406

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