凋亡抑制蛋白在细胞凋亡中的调节作用

被引：3

作者：

张韡

机构：

[1] 上海第二医科大学附属瑞金医院传染科上海

来源：

免疫学杂志 | 2003年 / S1期

关键词：

细胞凋亡; 凋亡抑制蛋白; Caspase蛋白酶;

D O I：

暂无

中图分类号：

R329 [人体组织学];

学科分类号：

100107 [人体解剖与组织胚胎学（人体解剖学、组织与胚胎学）];

摘要：

凋亡抑制蛋白(IAP)家族是至今发现的惟一一种内源性Caspase蛋白酶抑制剂,在细胞凋亡中发挥重要的调节作用。本文结合近年来的研究进展,综述了Caspase在凋亡中的作用、IAP家族蛋白分子的结构特征、抗凋亡作用机制以及IAPs抗凋亡作用的负调控。进一步认识细胞凋亡中复杂的调控机制,为寻找与凋亡紊乱相关的疾病治疗提供了重要靶向。

引用

收藏

页码：83 / 86

页数：4

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