FoxOs与骨质疏松

被引：7

作者：

李近 ^{[1
,2
]}

杨亚军 ^{[1
,2
]}

刘钰瑜 ^{[1
,2
]}

机构：

[1] 广东医学院药理学教研室

[2] 广东天然药物研究与开发重点实验室

来源：

中国药理学通报 | 2016年 / 32卷 / 02期

基金：

广东省科技计划;

关键词：

FoxOs; 骨质疏松; 氧化应激; 活性氧自由基(ROS); 发病机制; 防治策略;

D O I：

暂无

中图分类号：

R580 [];

学科分类号：

摘要：

FoxOs转录因子属于又头框蛋白(forkhead proteins)家族中的一个亚类,主要参与细胞凋亡、DNA修复和清除活性氧自由基(ROS)过程。越来越多的证据表明,FoxOs介导的氧化应激能够破坏骨代谢相关细胞的氧化还原平衡,进而影响骨质疏松发生和发展的进程。该文主要综述FoxOs与骨质疏松的关系,为探讨骨质疏松发病机制及防治策略研究提供参考。

引用

页码：169 / 171

页数：3

共 13 条

[1] FoxO/Wnt通路在氧化应激介导的骨质疏松中的调控机制
杨亚军
崔燎
[J]. 中国药理学通报 , 2013, (01) : 27 - 30
[2] Tanshinol Attenuates the Deleterious Effects of Oxidative Stress on Osteoblastic Differentiation via Wnt/FoxO3a Signaling[J] . Yajun Yang,Yanjie Su,Dongtao Wang,Yahui Chen,Tie Wu,Gang Li,Xuegang Sun,Liao Cui,Mohammad Abdollahi.Oxidative Medicine and Cellular Longevity . 2013
[3] FOXOs attenuate bone formation by suppressing Wnt signaling
Iyer, Srividhya
Ambrogini, Elena
Bartell, Shoshana M.
Han, Li
Roberson, Paula K.
de Cabo, Rafael
Jilka, Robert L.
Weinstein, Robert S.
O'Brien, Charles A.
Manolagas, Stavros C.
Almeida, Maria
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (08) : 3409 - 3419
[4] Current overview of functions of FoxO proteins, with special regards to cellular homeostasis, cell response to stress, as well as inflammation and aging[J] . M W?troba,D Ma?lińska,S Ma?liński.Advances in Medical Sciences . 2012 (2)
[5] Unraveling the role of FoxOs in bone-Insights from mouse models
Almeida, Maria
[J]. BONE, 2011, 49 (03) : 319 - 327
[6] FoxO1 Is a Positive Regulator of Bone Formation by Favoring Protein Synthesis and Resistance to Oxidative Stress in Osteoblasts
Rached, Marie-Therese
Kode, Aruna
Xu, Lili
Yoshikawa, Yoshihiro
Paik, Ji-Hye
DePinho, Ronald A.
Kousteni, Stavroula
[J]. CELL METABOLISM, 2010, 11 (02) : 147 - 160
[7] FoxO-Mediated Defense against Oxidative Stress in Osteoblasts Is Indispensable for Skeletal Homeostasis in Mice[J] . Elena Ambrogini,Maria Almeida,Marta Martin-Millan,Ji-Hye Paik,Ronald A. DePinho,Li Han,Joseph Goellner,Robert S. Weinstein,Robert L. Jilka,Charles A. O’Brien,Stavros C. Manolagas.Cell Metabolism . 2010 (2)
[8] Insulin Signaling in Osteoblasts Integrates Bone Remodeling and Energy Metabolism
Ferron, Mathieu
Wei, Jianwen
Yoshizawa, Tatsuya
Del Fattore, Andrea
DePinho, Ronald A.
Teti, Anna
Ducy, Patricia
Karsenty, Gerard
[J]. CELL, 2010, 142 (02) : 296 - 308
[9] FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice
Rached, Marie-Therese
Kode, Aruna
Silva, Barbara C.
Jung, Dae Young
Gray, Susan
Ong, Helena
Paik, Ji-Hye
DePinho, Ronald A.
Kim, Jason K.
Karsenty, Gerard
Kousteni, Stavroula
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (01) : 357 - 368
[10] Excess mortality following hip fracture: a systematic epidemiological review[J] . B. Abrahamsen,T. Staa,R. Ariely,M. Olson,C. Cooper.Osteoporosis International . 2009 (10)

← 1 2 →