FoxO/Wnt通路在氧化应激介导的骨质疏松中的调控机制

被引：31

作者：

杨亚军 ^{[1
]}

崔燎 ^{[1
,2
]}

机构：

[1] 不详

[2] 南方医科大学中医药学院

[3] 不详

[4] 广东医学院药理学教研室

[5] 不详

来源：

中国药理学通报 | 2013年 / 01期

关键词：

活性氧自由基; 氧化应激; Wnt; FoxO; β-catenin; 骨质疏松; 抗氧化剂;

D O I：

暂无

中图分类号：

R580 [];

学科分类号：

摘要：

在衰老机体中,过量的活性氧自由基(ROS)可产生氧化应激(OS),降低骨量和骨质量,诱发骨质疏松。β-catenin与Wnt通路下游的TCF作用可调控骨形成,与FoxO作用可产生抗OS作用,"以衰老和氧化应激为中心"已成为骨质疏松研究的新焦点,抗氧化剂具有防治骨质疏松潜力。

引用

页码：27 / 30

页数：4

共 15 条

[1] 白藜芦醇对脑缺血/再灌注氧化应激损伤保护机制的研究进展
任俊伟
杨琴
[J]. 中国药理学通报, 2011, (04) : 448 - 451
[2] Malondialdehyde, Bcl-2, Superoxide Dismutase and Glutathione Peroxidase may Mediate the Association of Sonic Hedgehog Protein and Oxidative Stress in Autism[J] . Ahmad Ghanizadeh.Neurochemical Research . 2012 (4)
[3] Rho kinase inhibition by fasudil exerts antioxidant effects in hypercholesterolemic rats
Ma, Zhihong
Zhang, Jianping
Ji, Ensheng
Cao, Gang
Li, Guoming
Chu, Li
[J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2011, 38 (10): : 688 - 694
[4] Unraveling the role of FoxOs in bone-Insights from mouse models
Almeida, Maria
[J]. BONE, 2011, 49 (03) : 319 - 327
[5] The WTX Tumor Suppressor Regulates Mesenchymal Progenitor Cell Fate Specification
Moisan, Annie
Rivera, Miguel N.
Lotinun, Sutada
Akhavanfard, Sara
Coffman, Erik J.
Cook, Edward B.
Stoykova, Svetlana
Mukherjee, Siddhartha
Schoonmaker, Jesse A.
Burger, Alexa
Kim, Woo Jae
Kronenberg, Henry M.
Baron, Roland
Haber, Daniel A.
Bardeesy, Nabeel
[J]. DEVELOPMENTAL CELL, 2011, 20 (05) : 583 - 596
[6] Expression of RANKL/OPG during bone remodeling in vivo
Tanaka, H.
Mine, T.
Ogasa, H.
Taguchi, T.
Liang, C. T.
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 411 (04) : 690 - 694
[7] Lipoic acid prevents oxidative stress in vitro and in vivo by an acute hyperphenylalaninemia chemically-induced in rat brain[J] . Tarsila Barros Moraes,Fernanda Zanin,Andrea da Rosa,Amanda de Oliveira,Juliana Coelho,Felipe Petrillo,Moacir Wajner,Carlos Severo Dutra-Filho.Journal of the Neurological Sciences . 2010 (1)
[8] From Estrogen-Centric to Aging and Oxidative Stress: A Revised Perspective of the Pathogenesis of Osteoporosis[J] . Stavros C. Manolagas.Endocrine Reviews . 2010 (3)
[9] Redox regulation of Wnt signalling via nucleoredoxin
Funato, Yosuke
Miki, Hiroaki
[J]. FREE RADICAL RESEARCH, 2010, 44 (04) : 379 - 388
[10] A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span
Lehtinen, Maria K.
Yuan, Zengqiang
Boag, Peter R.
Yang, Yue
Villen, Judit
Becker, Esther B. E.
DiBacco, Sara
de la Iglesia, Nuria
Gygi, Steven
Blackwell, T. Keith
Bonni, Azad
[J]. CELL, 2006, 125 (05) : 987 - 1001

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