Redox regulation of Wnt signalling via nucleoredoxin

被引：72

作者：

Funato, Yosuke ^{[1
]}

Miki, Hiroaki ^{[1
]}

机构：

[1] Osaka Univ, Inst Prot Res, Lab Intracellular Signaling, Suita, Osaka 5650871, Japan

来源：

FREE RADICAL RESEARCH | 2010年 / 44卷 / 04期

关键词：

PROTEIN PHOSPHATASE 2A; THIOREDOXIN-LIKE PROTEIN; MAMMARY ONCOGENE INT-1; CONE VIABILITY FACTOR; NF-KAPPA-B; BETA-CATENIN; OXIDATIVE STRESS; POLARITY GENE; CAENORHABDITIS-ELEGANS; TISSUE POLARITY;

D O I：

10.3109/10715761003610745

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Numerous studies indicate that reactive oxygen species (ROS) are not merely cellular by-products of respiration, but are able to modulate various signalling pathways and play certain physiological roles. Recent studies have revealed the importance of translating ROS-generation to activation/suppression of specific signalling pathways. The Wnt signalling pathway, which is essential for early development and stem cell maintenance, is also regulated by ROS. A thioredoxin-related protein, nucleoredoxin (NRX), governs ROS-stimulated Wnt signalling in a temporal manner. NRX usually interacts with Dishevelled (Dvl), an essential adaptor protein for Wnt signalling, and blocks the activation of the Wnt pathway. Oxidative stress causes dissociation of NRX from Dvl, which enables Dvl to activate the downstream Wnt signalling pathway. This study also presents the latest research findings on NRX and its related molecules.

引用

页码：379 / 388

页数：10

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