维生素D状态与心血管危险

被引：28

作者：

吉薇

蒋雄京

机构：

[1] 北京协和医学院中国医学科学院阜外心血管病医院心血管病研究所

来源：

心血管病学进展 | 2010年 / 31卷 / 03期

关键词：

维生素D; 心血管危险;

D O I：

暂无

中图分类号：

R54 [心脏、血管（循环系）疾病];

学科分类号：

100201 [内科学];

摘要：

已知维生素D最重要的功能是维持人体钙离子代谢的平衡。近些年来的研究发现维生素D受体广泛存在于人体的多种组织细胞中,因此维生素D是否还具有其他重要的生物学功能成为研究热点,其中维生素D缺乏与心血管风险的关系颇为引人注目。一些研究提示维生素D缺乏可能增加心血管风险,包括高血压、心力衰竭和缺血性心脏病等。但其致病机制和影响程度尚不十分明确。现综述了目前有关维生素D状态与心血管危险间关系的假设机制,并探讨为验证有关假设已进行的一些重要研究。

引用

页码：327 / 331

页数：5

共 15 条

[1]

Plasma 25-Hydroxyvitamin D and Regulation of the Renin-Angiotensin System in Humans [J].

Forman, John P. ;

Williams, Jonathan S. ;

Fisher, Naomi D. L. .

HYPERTENSION, 2010, 55 (05) :1283-1288

[2]

Plasma 25-Hydroxyvitamin D Concentration and Metabolic Syndrome Among Middle-Aged and Elderly Chinese Individuals [J].

Lu, Ling ;

Yu, Zhijie ;

Pan, An ;

Hu, Frank B. ;

Franco, Oscar H. ;

Li, Huaixing ;

Li, Xiaoying ;

Yang, Xilin ;

Chen, Yan ;

Lin, Xu .

DIABETES CARE, 2009, 32 (07) :1278-1283

[3]

Prevalence of Hypovitaminosis D in Cardiovascular Diseases (from the National Health and Nutrition Examination Survey 2001 to 2004) [J].

Kim, Dae Hyun ;

Sabour, Siamak ;

Sagar, Utpal N. ;

Adams, Suzanne ;

Whellan, David J. .

AMERICAN JOURNAL OF CARDIOLOGY, 2008, 102 (11) :1540-1544

[4]

A lifetime of aldosterone excess: Long-term consequences of altered regulation of aldosterone production for cardiovascular function [J].

Connell, John M. C. ;

MacKenzie, Scott M. ;

Freel, E. Marie ;

Fraser, Robert ;

Davies, Eleanor .

ENDOCRINE REVIEWS, 2008, 29 (02) :133-154

[5]

Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels [J].

Sugden, J. A. ;

Davies, J. I. ;

Witham, M. D. ;

Morris, A. D. ;

Struthers, A. D. .

DIABETIC MEDICINE, 2008, 25 (03) :320-325

[6]

Vitamin D3 in fat tissue [J].

Blum, Miriam ;

Dolnikowski, Gregory ;

Seyoum, Elias ;

Harris, Susan S. ;

Booth, Sarah L. ;

Peterson, James ;

Saltzman, Edward ;

Dawson-Hughes, Bess .

ENDOCRINE, 2008, 33 (01) :90-94

[7]

Vitamin D deficiency and risk of cardiovascular disease [J].

Wang, Thomas J. ;

Pencina, Michael J. ;

Booth, Sarah L. ;

Jacques, Paul F. ;

Ingelsson, Erik ;

Lanier, Katherine ;

Benjamin, Emelia J. ;

D'Agostino, Ralph B. ;

Wolf, Myles ;

Vasan, Ramachandran S. .

CIRCULATION, 2008, 117 (04) :503-511

[8]

Plasma 25-hydroxyvitamin D levels and risk of incident hypertension [J].

Forman, John P. ;

Giovannucci, Edward ;

Holmes, Michelle D. ;

Bischoff-Ferrari, Heike A. ;

Tworoger, Shelley S. ;

Willett, Walter C. ;

Curhan, Gary C. .

HYPERTENSION, 2007, 49 (05) :1063-1069

[9]

Vitamin D and disease prevention with special reference to cardiovascular disease [J].

Zittermann, Armin .

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 2006, 92 (01) :39-48

[10]

Vitamin D: a negative endocrine regulator of the renin–angiotensin system and blood pressure.[J].Yan Chun Li;Guilin Qiao;Milan Uskokovic;Wei Xiang;Wei Zheng;Juan Kong.Journal of Steroid Biochemistry and Molecular Biology.2004,

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