Vitamin D3 in fat tissue

被引:310
作者
Blum, Miriam [1 ]
Dolnikowski, Gregory [1 ]
Seyoum, Elias [1 ]
Harris, Susan S. [1 ]
Booth, Sarah L. [1 ]
Peterson, James [1 ]
Saltzman, Edward [1 ]
Dawson-Hughes, Bess [1 ]
机构
[1] Tufts Univ, Human Nutr Res Ctr Aging, Jean Mayer USDA, Boston, MA 02111 USA
关键词
vitamin D-3; fat tissue; serum; 25-Hydroxyvitamin D; obesity;
D O I
10.1007/s12020-008-9051-4
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The literature describing vitamin D content of fat tissue is extremely limited. We conducted a pilot study that measured the concentrations of vitamin D-3 in the fat tissue and serum of obese adults. These measurements were performed using a new liquid chromatography mass spectrometry (LC/MS) method. The objectives of this study were: to measure and report the vitamin D-3 concentration in serum and subcutaneous fat samples from obese individuals and to examine the association of vitamin D-3 in fat with vitamin D-3 in serum. This cross-sectional study was conducted in 17 obese men and women who were scheduled to undergo gastric bypass surgery. The mean vitamin D-3 concentration in subjects' subcutaneous fat tissue samples was 102.8 +/- 42.0 nmol/kg. The mean vitamin D-3 concentration in serum was 7.78 +.- 3.99 nmol/l. Vitamin D-3 concentrations of fat tissue and serum were positively correlated (r = 0.68, P = 0.003). Consistent with previous findings in obese subjects, subjects in this study had suboptimal vitamin D status as demonstrated by a mean 25-hydroxyvitamin D concentration of 43.3 +/- 15.4 nmol/l. In conclusion, fat tissue vitamin D-3 can be measured by LC/MS and is detectable in obese subjects with suboptimal vitamin D status. Compatible with the long-standing concept that fat tissue is a storage site for vitamin D, fat tissue and serum vitamin D-3 concentrations were positively correlated.
引用
收藏
页码:90 / 94
页数:5
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