芒果苷协同氟康唑抗耐药白念珠菌作用研究

被引：13

作者：

董怀怀

王元花

廖泽彬

姜远英

曹颖瑛

机构：

[1] 中国人民解放军第二军医大学药学院新药研究中心

来源：

中国真菌学杂志 | 2017年 / 12卷 / 02期

关键词：

耐药白念珠菌; 芒果苷; 氟康唑;

D O I：

暂无

中图分类号：

R379.4 [念珠菌];

学科分类号：

100103 [病原生物学];

摘要：

目的研究芒果苷与氟康唑合用对唑类耐药白念珠菌协同抗真菌的作用和机制。方法采用棋盘式微量稀释法测试芒果苷协同氟康唑对22株耐药白念珠菌的最小抑菌浓度MIC80;时间-杀菌曲线探究两药联用对4株耐药白念珠菌生长的抑制作用;药物生长抑制实验实验探究不同浓度芒果苷和不同浓度氟康唑协同抗耐药白念珠菌药效;通过实时定量RT-PCR检测两药联用时耐药基因CDR1、CDR2、MDR1表达水平。结果芒果苷联合氟康唑可产生协同抗唑类白念珠菌作用,协同指数(FICI)<0.5;两药合用对白念珠菌生长可产生抑制作用;两药合用降低耐药基因CDR1表达水平。结论芒果苷与氟康唑合用可产生协同抗唑类耐药白念珠菌作用。

引用

页码：78 / 82+85 +85

页数：6

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