Differential effects of the combination of caspofungin and terbinafine against Candida albicans, Candida dubliniensis and Candida kefyr

被引：18

作者：

Gil-Lamaignere, C ^{[1
]}

Müller, FMC ^{[1
]}

机构：

[1] Heidelberg Univ, Pediat Pulm & Infect Dis, Dept Pediat 3, D-69120 Heidelberg, Germany

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2004年 / 23卷 / 05期

关键词：

Candida spp; caspofungin; terbinafine; checkerboard; synergism; combination therapy;

D O I：

10.1016/j.ijantimicag.2003.10.005

中图分类号：

R51 [传染病];

学科分类号：

100401 [流行病与卫生统计学];

摘要：

The activity of caspofungin (CSP) combined with terbinafine (TRB) against Candida dubliniensis, Candida kefyr and azole-resistant Candida albicans was evaluated in vitro by checkerboard analysis. The combination of CSP with TRB resulted in positive interactive effects in vitro against C. albicans and C. kefyr but not against C. dubliniensis. Moreover, true synergism was observed only against TRB resistant strains which became susceptible to this drug in the presence of CSP. In contrast, indifference was observed against strains that were already sensitive to TRB indicating that CSP may inhibit resistance to TRB. (C) 2004 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：520 / 523

页数：4

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