基于TCMSP对玫瑰花黄酮和挥发油防治心血管疾病的协同作用及其机制研究

被引：34

作者：

袁长胜

陈文

机构：

[1] 石河子大学药学院

来源：

石河子大学学报(自然科学版) | 2016年 / 34卷 / 06期

关键词：

玫瑰花黄酮; 玫瑰花挥发油; TCMSP; 协同心肌保护;

D O I：

暂无

中图分类号：

R29 [中国少数民族医学];

学科分类号：

100513 [民族医学];

摘要：

为对芳香性维药玫瑰花黄酮和挥发油的协同心血管药理作用及机制进行探讨。利用中药系统药理学(TCMSP)工具和策略进行研究,建立玫瑰花黄酮和挥发油候选化合物库,利用Sys DT模型筛选二者作用靶点,并对其相关疾病进行映射,最后进行预测分析。结果显示,建立了玫瑰花黄酮和挥发油候选化合物库,并筛得了玫瑰花黄酮和挥发油的共同作用靶点7个。此外,黄酮高频作用靶点10个,挥发油高频作用靶点6个。通过疾病映射和分析发现,这些靶点都与心肌保护有一定的关系,挥发油的有些靶点还与血管舒缩活动有关。由此可知,根据预测结果,推断出玫瑰花黄酮和挥发油具有协同的心肌保护作用,为后续的玫瑰花药理作用的实验研究提供了一定的指导。

引用

页码：731 / 738

页数：8

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