快速老化小鼠SAMP8研究进展

被引：23

作者：

周伟勤 ^{[1
]}

毕明刚 ^{[1
,2
]}

杜冠华 ^{[2
]}

机构：

[1] 中国医学科学院药用植物研究所

[2] 中国医学科学院药物研究所

来源：

中国药理学通报 | 2009年 / 05期

关键词：

快速老化小鼠; 阿尔采末病; 动物模型;

D O I：

暂无

中图分类号：

R-332 [医用实验动物学];

学科分类号：

摘要：

快速老化小鼠SAMP8(senescence-accelerated mouseprone/8)是一个从普通的遗传群AKR/J系小鼠中通过表型选择培育出的快速老化小鼠,表现为早期增龄性学习记忆缺陷,同时伴有Aβ淀粉样蛋白沉积,是目前公认的有效的研究阿尔采末病(Alzheimer’s disease,AD)动物模型。同属SAMR1表现为抗快速老化,具有正常的老化特性,常用作正常对照。目前SAMP8已被广泛应用于研究快速学习记忆缺陷的发病机制,以及评价抗衰老及改善学习记忆功能的药物等。

引用

页码：565 / 568

页数：4

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