乙醇封管对导管相关性血流感染预防效果的Meta分析

被引:6
作者
张慧 [1 ]
李夏卉 [2 ]
叶艳胜 [2 ]
胡汝均 [2 ]
机构
[1] 四川大学华西医院医院感染管理部
[2] 四川大学华西临床医学院护理系
关键词
乙醇; 封管; 感染; Meta分析; 随机对照试验;
D O I
暂无
中图分类号
R473 [专科护理学];
学科分类号
101102 [成人与老年护理学];
摘要
目的评价乙醇封管对导管相关性血流感染的预防效果。方法计算机检索PubMed、The Cochrane Library、EMbase、CBM、CNKI数据库从2007年1月至2017年7月的相关文献,纳入乙醇封管用于预防导管相关性血流感染的随机对照试验,由2名研究者独立筛选文献、提取资料和评价纳入研究的方法学质量。结果共纳入9篇文献研究,2443例患者。结果显示,乙醇封管组CRBSI发生率低于对照组[RR=0.57,95%CI(0.39,0.83),P=0.003],而两组在导管出口部位感染、不良反应、血栓和导管功能不良方面没有统计学差异。结论乙醇封管能够减少导管相关性血流感染的发生;受所纳入研究质量的限制,尚需要开展更多高质量研究予以验证。
引用
收藏
页码:4159 / 4162+4194 +4194
页数:5
相关论文
共 9 条
[1]
乙醇与常规肝素封管在血液透析长期留置导管中的比较研究 [J].
唐建英 ;
雷湫宇 ;
曾薇 ;
王沂芹 ;
王代红 ;
赵景宏 .
现代生物医学进展, 2015, 15 (10) :1866-1869
[2]
乙醇封管在维持性血液透析长期留置导管患者中的应用研究 [J].
杨金芳 ;
刘宏 ;
高民 ;
佘丽平 ;
张留平 ;
王越 .
中华医院感染学杂志, 2013, 23 (02) :318-319
[3]
Prevention of central venous catheter-associated bloodstream infections in paediatric oncology patients using 70% ethanol locks: A randomised controlled multi-centre trial [J].
Schoot, Reineke A. ;
van Ommen, C. Heleen ;
Stijnen, Theo ;
Tissing, Wim J. E. ;
Michiels, Erna ;
Abbink, Floor C. H. ;
Raphael, Martine F. ;
Heij, Hugo A. ;
Lieverst, Jan A. ;
Spanjaard, Lodewijk ;
Zwaan, C. Michel ;
Caron, Huib N. ;
van de Wetering, Marianne D. .
EUROPEAN JOURNAL OF CANCER, 2015, 51 (14) :2031-2038
[4]
Ethanol versus heparin locks for the prevention of central venous catheter-associated bloodstream infections: a randomized trial in adult haematology patients with Hickman devices [J].
Worth, L. J. ;
Slavin, M. A. ;
Heath, S. ;
Szer, J. ;
Grigg, A. P. .
JOURNAL OF HOSPITAL INFECTION, 2014, 88 (01) :48-51
[5]
Catheter lock technique: in vitro efficacy of ethanol for eradication of methicillin-resistant staphylococcal biofilm compared with other agents [J].
Chaudhury, Abhijit ;
Rangineni, Jayaprada ;
Venkatramana, B. .
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 2012, 65 (02) :305-308
[6]
Ethanol lock therapy to reduce the incidence of catheter-related bloodstream infections in home parenteral nutrition patients with intestinal failure: preliminary experience [J].
Wales, Paul W. ;
Kosar, Christina ;
Carricato, Megan ;
de Silva, Nicole ;
Lang, Karen ;
Avitzur, Yaron .
JOURNAL OF PEDIATRIC SURGERY, 2011, 46 (05) :951-956
[7]
Guidelines for the prevention of intravascular catheter-related infections [J].
O'Grady, Naomi P. ;
Alexander, Mary ;
Burns, Lillian A. ;
Dellinger, E. Patchen ;
Garland, Jeffrey ;
Heard, Stephen O. ;
Lipsett, Pamela A. ;
Masur, Henry ;
Mermel, Leonard A. ;
Pearson, Michele L. ;
Raad, Issam I. ;
Randolph, Adrienne G. ;
Rupp, Mark E. ;
Saint, Sanjay .
AMERICAN JOURNAL OF INFECTION CONTROL, 2011, 39 (04) :S1-S34
[8]
Preliminary results of a phase I trial of prophylactic ethanol-lock administration to prevent mediport catheter-related bloodstream infections [J].
Kayton, Mark L. ;
Garmey, Edward G. ;
Ishill, Nicole M. ;
Cheung, Nai-Kong V. ;
Kushner, Brian H. ;
Kramer, Kim ;
Modak, Shakeel ;
Rossetto, Carol ;
Hennelly, Courtney ;
Doyle, Melissa Parra ;
Rosenberg, Shoshana ;
Santoro, Olga ;
La Quaglia, Michael P. .
JOURNAL OF PEDIATRIC SURGERY, 2010, 45 (10) :1961-1966
[9]
Ethanol impairs coagulation and fibrinolysis in whole blood:: a study performed with rotational thromboelastometry [J].
Engstrom, Martin ;
Schott, Ulf ;
Reinstrup, Peter .
BLOOD COAGULATION & FIBRINOLYSIS, 2006, 17 (08) :661-665