Ethanol versus heparin locks for the prevention of central venous catheter-associated bloodstream infections: a randomized trial in adult haematology patients with Hickman devices

被引：23

作者：

Worth, L. J. ^{[1
]}

Slavin, M. A. ^{[1
,2
]}

Heath, S. ^{[3
,4
,5
]}

Szer, J. ^{[3
,4
,5
]}

Grigg, A. P. ^{[6
]}

机构：

[1] Peter MacCallum Canc Ctr, Dept Infect Dis & Infect Prevent, Melbourne, Vic 8006, Australia

[2] Royal Melbourne Hosp, Victorian Infect Dis Serv, Melbourne, Vic, Australia

[3] Royal Melbourne Hosp, Dept Clin Haematol, Melbourne, Vic, Australia

[4] Royal Melbourne Hosp, Bone Marrow Transplant Serv, Melbourne, Vic, Australia

[5] Univ Melbourne, Melbourne, Vic, Australia

[6] Austin Hlth, Dept Haematol, Heidelberg, Vic, Australia

来源：

JOURNAL OF HOSPITAL INFECTION | 2014年 / 88卷 / 01期

关键词：

Bloodstream infection; Bone marrow transplantation; Central venous catheter; Ethanol lock; Haematology; Prophylaxis; SURVEILLANCE;

D O I：

10.1016/j.jhin.2014.06.007

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

100235 [预防医学];

摘要：

The effectiveness of ethanol locks for prevention of central venous catheter (CVC)-associated bloodstream infection (CLABSI) in adult haematology patients has not been thoroughly evaluated. This study aimed to compare prospectively heparinized saline with 70% ethanol locks using 2 h dwell time in patients with tunnelled CVCs. In saline (N = 43) and ethanol (N = 42) groups, CLABSI rates were 6.0 [95% confidence interval (CI): 3.4-9.8] and 4.1 (95% CI: 1.9-7.7) per 1000 CVC days, respectively (P = 0.42). In the ethanol group, two exit-site infections and one tunnel/pocket infection were observed. Reduction in device-associated infection was not achieved with prophylactic 70% ethanol locks in patients with haematological malignancy and tunnelled CVCs. (C) 2014 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

引用

页码：48 / 51

页数：4

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