3种氯酚化合物对大型溞的联合毒性

被引：16

作者：

张亚辉

曹莹

王一喆

刘征涛

机构：

[1] 中国环境科学研究院环境基准与风险评估国家重点实验室

来源：

生态毒理学报 | 2011年 / 04期

关键词：

联合毒性; 氯酚; 大型溞; 浓度加和; 独立作用;

D O I：

暂无

中图分类号：

X174 [环境动物学];

学科分类号：

摘要：

氯酚类化合物是我国水体中广泛存在的一类优先控制污染物,以大型溞(Daphnia magna)为试验生物,测定了2,4-二氯酚、2,4,6-三氯酚和五氯酚对大型溞的48h致死的单一毒性和联合毒性。基于单一氯酚化合物的浓度-效应曲线,运用浓度加和(CA)与独立作用(IA)2个模型对2种等毒性浓度比的混合物(Mix-LC50和Mix-LC1)的联合毒性进行预测。通过氯酚混合物的观测数据的95%置信区间与CA和IA模型预测的浓度-效应曲线进行比较分析,结果表明,CA预测曲线与Mix-LC50和Mix-LC1这2种混合物的95%置信区间相近,而与IA的预测相差较大。以模型偏差率(MDR)表示CA或者IA预测效应浓度和观测值之间的偏差,在不同效应水平下CA对2种混合物的MDR值均小于1.5,说明CA能够预测3种氯酚化合物对大型溞的联合毒性。

引用

页码：403 / 409

页数：7

共 47 条

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