Inflammation: a mechanism of depression?

被引：4

作者：

Qiu-Qin Han

Jin Yu

机构：

[1] DepartmentofIntegrativeMedicineandNeurobiology,StateKeyLaboratoryofMedicalNeurobiology,InstitutesofBrainScience,ShanghaiMedicalCollege,FudanUniversity

来源：

NeuroscienceBulletin | 2014年 / 30卷 / 03期

关键词：

depression; inflammation; cytokines; hypothalamic-pituitary-adrenal axis; 5-HT; neuroplasticity;

D O I：

暂无

中图分类号：

R749.4 [情感性精神病];

学科分类号：

100205 ;

摘要：

In recent decades, major depression has become more prevalent and research has shown that immune activation and cytokine production may be involved. This review is mainly focused on the contribution of inflammation to depression. We first briefly introduce the inflammatory biomarkers of depression, then discuss the sources of cytokines in the brain, and finally describe the neuroimmunological mechanisms underlying the association between inflammation and depression.

引用

页码：515 / 523

页数：9

共 51 条

[1] 焦虑抑郁情绪对烧伤后创面愈合及TNF-α、IL-6水平的影响 [J].

吴孝苹 ;

王东 ;

宋中金 ;

孙充洲 ;

肖晓兰 ;

何友德 ;

王才明 ;

孙学礼 .

四川大学学报(医学版), 2008, (01) :105-107

[2]

N -acetyl-cysteine prevents toxic oxidative effects induced by IFN- ?± in human neurons[J] . Silvia Alboni,Lara Gibellini,Claudia Montanari,Cristina Benatti,Stefania Benatti,Fabio Tascedda,Nicoletta Brunello,Andrea Cossarizza,Carmine M. Pariante.The International Journal of Neuropsychopharmacology . 2013 (8)

[3]

Ketamine as a new treatment for depression: A review of its efficacy and adverse effects[J] . Natalie Katalinic,Rosalyn Lai,Andrew Somogyi,Philip B Mitchell,Paul Glue,Colleen K Loo.Australian & New Zealand Journal of Psychiatry . 2013 (8)

[4] A review of Atypical depression in relation to the course of depression and changes in HPA axis organization [J].

O'Keane, Veronica ;

Frodl, Thomas ;

Dinan, Timothy G. .

PSYCHONEUROENDOCRINOLOGY, 2012, 37 (10) :1589-1599

[5]

Using optogenetics to translate the “inflammatory dialogue” between heart and brain in the context of stress[J] . Jinbo Cheng,Jie Zhang,Caiyi Lu,Liping Wang.Neuroscience Bulletin . 2012 (4)

[6]

Immune system to brain signaling: Neuropsychopharmacological implications[J] . Lucile Capuron,Andrew H. Miller.Pharmacology and Therapeutics . 2011 (2)

[7]

Cytokines and depression: findings, issues, and treatment implications[J] . Christopher F. Sharpley,Linda L. Agnew.Reviews in the Neurosciences . 2011 (3)

[8] Regulatory T cells increased while IL-1β decreased during antidepressant therapy [J].

Himmerich, Hubertus ;

Milenovic, Sasa ;

Fulda, Stephany ;

Plumakers, Birgit ;

Sheldrick, Abigail J. ;

Michel, Tanja M. ;

Kircher, Tilo ;

Rink, Lothar .

JOURNAL OF PSYCHIATRIC RESEARCH, 2010, 44 (15) :1052-1057

[9] A Meta-Analysis of Cytokines in Major Depression [J].

Dowlati, Yekta ;

Herrmann, Nathan ;

Swardfager, Walter ;

Liu, Helena ;

Sham, Lauren ;

Reim, Elyse K. ;

Lanctot, Krista L. .

BIOLOGICAL PSYCHIATRY, 2010, 67 (05) :446-457

[10] Interleukin-1β Serum Levels is Increased in Antidepressant-Free Elderly Depressed Patients [J].

Diniz, Breno Satler ;

Teixeira, Antonio Lucio ;

Talib, Leda ;

Gattaz, Wagner Farid ;

Forlenza, Orestes Vicente .

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2010, 18 (02) :172-176

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