Inflammation: a mechanism of depression?

被引：4

作者：

Qiu-Qin Han

Jin Yu

机构：

[1] DepartmentofIntegrativeMedicineandNeurobiology,StateKeyLaboratoryofMedicalNeurobiology,InstitutesofBrainScience,ShanghaiMedicalCollege,FudanUniversity

来源：

NeuroscienceBulletin | 2014年 / 30卷 / 03期

关键词：

depression; inflammation; cytokines; hypothalamic-pituitary-adrenal axis; 5-HT; neuroplasticity;

D O I：

暂无

中图分类号：

R749.4 [情感性精神病];

学科分类号：

100205 ;

摘要：

In recent decades, major depression has become more prevalent and research has shown that immune activation and cytokine production may be involved. This review is mainly focused on the contribution of inflammation to depression. We first briefly introduce the inflammatory biomarkers of depression, then discuss the sources of cytokines in the brain, and finally describe the neuroimmunological mechanisms underlying the association between inflammation and depression.

引用

页码：515 / 523

页数：9

共 51 条

[11] Higher plasma interleukin-6 (IL-6) level is associated with SSRI- or SNRI-refractory depression [J].

Yoshimura, Reiji ;

Hori, Hikaru ;

Ikenouchi-Sugita, Atsuko ;

Umene-Nakano, Wakako ;

Ueda, Nobuhisa ;

Nakamura, Jun .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2009, 33 (04) :722-726

[12]

Changes in the prevalence of major depression and comorbid substance use disorders in the United States between 1991-1992 and 2001-2002 .2 Compton Wilson M,Conway Kevin P,Stinson Frederick S,Grant Bridget F. The American journal of psychiatry . 2006

[13]

Sex and depression in the National Comorbidity Survey I: Lifetime prevalence, chronicity and recurrence .2 Ronald C. Kessler,Katherine A. McGonagle,Marvin Swartz,Dan G. Blazer,Christopher B. Nelson. Journal of Affective Disorders . 1993

[14]

Cytokine, Sickness Behavior, and Depression[J] . Robert Dantzer.Immunology and Allergy Clinics of North America . 2009 (2)

[15]

Effects of eicosapentaenoic acid and fluoxetine on plasma cortisol, serum interleukin-1beta and interleukin-6 concentrations in patients with major depressive disorder[J] . Shima Jazayeri,Seyed A. Keshavarz,Mehdi Tehrani-Doost,Mahmood Djalali,Mostafa Hosseini,Homayoun Amini,Maryam Chamari,Abolghassem Djazayery.Psychiatry Research . 2009 (1)

[16]

Pro- and Anti-Inflammatory Cytokine Balance in Major Depression: Effect of Sertraline Therapy[J] . Levent Sutcigil,Cagatay Oktenli,Ugur Musabak,Ali Bozkurt,Adnan Cansever,Ozcan Uzun,S. Yavuz Sanisoglu,Zeki Yesilova,Nahit Ozmenler,Aytekin Ozsahin,Ali Sengul,Ethan M. Shevach.Clinical and Developmental Immunology . 2008

[17]

Immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) on human T lymphocyte function and gene expression[J] . Michal Taler,Irit Gil-Ad,Liat Lomnitski,Inna Korov,Ehud Baharav,Meytal Bar,Amichay Zolokov,Abraham Weizman.European Neuropsychopharmacology . 2007 (12)

[18]

Involvement of pro-inflammatory cytokines and microglia in an age-associated neurodegeneration model, the SAMP10 mouse[J] . Naoko Kumagai,Yoichi Chiba,Masamichi Hosono,Masato Fujii,Noriko Kawamura,Hiromi Keino,Keisuke Yoshikawa,Sanae Ishii,Yuko Saitoh,Mamoru Satoh,Atsuyoshi Shimada,Masanori Hosokawa.Brain Research . 2007

[19]

Effects of Interferon-Alpha on Rhesus Monkeys: A Nonhuman Primate Model of Cytokine-Induced Depression[J] . Jennifer C. Felger,Oyetunde Alagbe,Fang Hu,Deborah Mook,Amanda A. Freeman,Mar M. Sanchez,Ned H. Kalin,Emiliangelo Ratti,Charles B. Nemeroff,Andrew H. Miller.Biological Psychiatry . 2007 (11)

[20] Brain-immune communication pathways [J].

Quan, Ning ;

Banks, William A. .

BRAIN BEHAVIOR AND IMMUNITY, 2007, 21 (06) :727-735

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