非布司他在痛风石性痛风患者中降尿酸的临床疗效观察

被引：2

作者：

邓琼

徐朝焰

机构：

[1] 福建医科大学附属三明第一医院

来源：

基层医学论坛 | 2018年 / 22卷 / 25期

关键词：

痛风; 痛风石; 非布司他; 尿酸;

D O I：

10.19435/j.1672-1721.2018.25.036

中图分类号：

R589.7 [嘌呤（Purine）代谢障碍];

学科分类号：

100201 [内科学];

摘要：

目的探讨非布司他在痛风石性痛风患者中降尿酸的临床疗效。方法选取2016年1月—7月在我院诊治的70例痛风石性痛风患者,随机将其分成观察与对照组,每组35例。观察组口服非布司他治疗,对照组口服别嘌醇治疗,分别检测2组患者治疗前后血尿酸水平,并记录20个星期后血尿酸水平<300μmol/L的例数。结果治疗后2组患者血尿酸水平均较治疗前降低,并且观察组患者血尿酸含量明显低于对照组,差异有统计学意义(P<0.05);20个星期后观察组患者血尿酸水平低于300μmol/L的例数多于对照组,差异有统计学意义(P<0.05)。结论非布司他治疗痛风石性痛风,可有效降低尿酸,安全性高,值得推广应用。

引用

页码：3552 / 3554

页数：3

共 10 条

[1]

2016中国痛风诊疗指南.[J].中华医学会风湿病学分会;.中华内科杂志.2016, 11

[2]

别嘌醇超敏反应研究进展 [J].

陈泽娜 ;

古洁若 .

新医学, 2016, 47 (03) :142-145

[3]

难治性痛风石性痛风的治疗 [J].

刘湘源 .

中华临床医师杂志(电子版), 2008, (06) :619-623

[4]

Toward Development of a Tophus Impact Questionnaire A Qualitative Study Exploring the Experience of People With Tophaceous Gout [J].

Aati, Opetaia ;

Taylor, William J. ;

Horne, Anne ;

Dalbeth, Nicola .

JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, 2014, 20 (05) :251-255

[5]

Diabetes and gout: efficacy and safety of febuxostat and allopurinol [J].

Becker, M. A. ;

MacDonald, P. A. ;

Hunt, B. J. ;

Jackson, R. L. .

DIABETES OBESITY & METABOLISM, 2013, 15 (11) :1049-1055

[6]

Allopurinol hypersensitivity is primarily mediated by dose-dependent oxypurinol-specific T cell response [J].

Yun, J. ;

Mattsson, J. ;

Schnyder, K. ;

Fontana, S. ;

Largiader, C. R. ;

Pichler, W. J. ;

Yerly, D. .

CLINICAL AND EXPERIMENTAL ALLERGY, 2013, 43 (11) :1246-1255

[7]

Chronic gout in the elderly [J].

Bolzetta, Francesco ;

Veronese, Nicola ;

Manzato, Enzo ;

Sergi, Giuseppe .

AGING CLINICAL AND EXPERIMENTAL RESEARCH, 2013, 25 (02) :129-137

[8]

2012 American College of Rheumatology guidelines for management of gout. Part 2: Therapy and antiinflammatory prophylaxis of acute gouty arthritis [J].

Khanna, Dinesh ;

Khanna, Puja P. ;

Fitzgerald, John D. ;

Singh, Manjit K. ;

Bae, Sangmee ;

Neogi, Tuhina ;

Pillinger, Michael H. ;

Merill, Joan ;

Lee, Susan ;

Prakash, Shraddha ;

Kaldas, Marian ;

Gogia, Maneesh ;

Perez-Ruiz, Fernando ;

Taylor, Will ;

Liote, Frederic ;

Choi, Hyon ;

Singh, Jasvinder A. ;

Dalbeth, Nicola ;

Kaplan, Sanford ;

Niyyar, Vandana ;

Jones, Danielle ;

Yarows, Steven A. ;

Roessler, Blake ;

Kerr, Gail ;

King, Charles ;

Levy, Gerald ;

Furst, Daniel E. ;

Edwards, N. Lawrence ;

Mandell, Brian ;

Schumacher, H. Ralph ;

Robbins, Mark ;

Wenger, Neil ;

Terkeltaub, Robert .

ARTHRITIS CARE & RESEARCH, 2012, 64 (10) :1447-1461

[9]

A Repeated Oral Administration Study of Febuxostat (TMX-67); a Non-Purine-Selective Inhibitor of Xanthine Oxidase; in Patients With Impaired Renal Function in Japan: Pharmacokinetic and Pharmacodynamic Study.[J].Hosoya Tatsuo;Ohno Iwao.Journal of Clinical Rheumatology.2011, 4 Su

[10]

内科学.[M].叶任高等; 编著.人民卫生出版社.2004,

← 1 →