Neuroprotective effect of ischemic preconditioning in focal cerebral infarction: relationship with upregulation of vascular endothelial growth factor

被引：13

作者：

Yong Liu ^{[1
,2
]}

Suiqiang Zhu ^{[1
]}

Yunfu Wang ^{[2
]}

Jingquan Hu ^{[2
]}

Lili Xu ^{[2
]}

Li Ding ^{[2
]}

Guangjian Liu ^{[2
]}

机构：

[1] Department of Neurology, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology

[2] Department of Neurology, Taihe Hospital Affiliated to Hubei University of Medicine

来源：

Neural Regeneration Research | 2014年 / 9卷 / 11期

关键词：

nerve regeneration; brain injury; transient ischemic attack; ischemic preconditioning; ischemia-reperfusion; focal cerebral infarction; infarct volume ratio; vascular endothelial growth factor; protection; mechanism; neural regeneration;

D O I：

暂无

中图分类号：

R743.31 [短暂性脑缺血];

学科分类号：

1002 ;

摘要：

Neuroprotection by ischemic preconditioning has been confirmed by many studies, but the precise mechanism remains unclear. In the present study, we performed cerebral ischemic preconditioning in rats by simulating a transient ischemic attack twice(each a 20-minute occlusion of the middle cerebral artery) before inducing focal cerebral infarction(2 hour occlusion-reperfusion in the same artery). We also explored the mechanism underlying the neuroprotective effect of ischemic preconditioning. Seven days after occlusion-reperfusion, tetrazolium chloride staining and immunohistochemistry revealed that the infarct volume was significantly smaller in the group that underwent preconditioning than in the model group. Furthermore, vascular endothelial growth factor immunoreactivity was considerably greater in the hippocampal CA3 region of preconditioned rats than model rats. Our results suggest that the protective effects of ischemic preconditioning on focal cerebral infarction are associated with upregulation of vascular endothelial growth factor.

引用

页码：1117 / 1121

页数：5

共 15 条

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