肾脏固有细胞的表型转化特征及其病理生理意义

被引:28
作者
王玉
李晓玫
机构
[1] 北京大学第一医院肾内科,北京大学第一医院肾内科北京大学肾脏病研究所,北京,北京大学肾脏病研究所,北京
关键词
肾; 表型;
D O I
暂无
中图分类号
R363 [病理生理学];
学科分类号
100104 ;
摘要
Increasing evidence has proved that phenotypic changes occured in residential renal cells during the process of renal diseases. The phenotypic change of mesangial cell plays a key role in the development of glomerular sclerosis, while the phenotypic changes of tubulo-interstitial cells have close relationship with the progress of interstitial fibrosis. Understandings of these phenotypic changes and their regulations may help us know better of the mechanism of renal diseases and find out ways to block the disease development.
引用
收藏
页码:136 / 140
页数:5
相关论文
共 32 条
[1]   肾脏固有细胞和浸润细胞在肾小管间质病变中的作用 [J].
杨莉 ;
李晓玫 ;
王海燕 .
中国病理生理杂志, 2002, (08) :128-132
[2]   人类肾小球肾炎中肾小管及间质细胞表型转化的研究 [J].
王玉 ;
李晓玫 ;
邹万忠 ;
王海燕 .
中华肾脏病杂志, 2000, (01) :7-10
[3]   Expression of cytoskeletal proteins during the course of experimental diabetic nephropathy [J].
Sanai, T ;
Sobka, T ;
Johnson, T ;
El-Essawy, M ;
Muchaneta-Kubara, EC ;
Gharbia, OB ;
Oldroyd, S ;
El Nahas, AM .
DIABETOLOGIA, 2000, 43 (01) :91-100
[4]   肾小球肾炎中系膜细胞α-平滑肌肌动蛋白表达与细胞表型变化的关系 [J].
王玉 ;
邹万忠 ;
李晓玫 .
中华肾脏病杂志, 1998, (04) :4-8
[5]  
Demonstration of collagen type IV and alpha smooth muscle actin in renal fibrotic injury in man. Groma V. Nephrology Dialysis Transplantation . 1998
[6]  
Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats. Ng Y Y,Huang T P,Yang W C,et al. Kidney International . 1998
[7]  
FGF-1 in normal and regenerating kidney: expression in mononuclear, interstitial, and regenerating epithelial cells. Ichimura T,Maier Jam,Macaig T,et al. American Journal of Physiology . 1995
[8]  
Expression of heat shock protein 47 in gentamycin treated rat kidneys. Cheng M,Razzaque MS,Nazneen A,et al. International Journal of Experimental Pathology . 1998
[9]  
Expression of vimentin and cytokeratin types of intermediate filament proteins in developing and adult human kidney. Holthofer H,Mietinen A,Lehtov P,et al. Laboratory Investigation . 1984
[10]  
Differential patterns of endothelial cell activation in renal and pulmonary vascular disease in scleroderma. Stratton RJ,Coghlan JG,Pearson JD,et al. Quarterly Journal of Mathematics . 1998