大剂量他汀强化降脂治疗更多获益及逆转斑块的研究进展

被引:7
作者
张超伟
刘滨
机构
[1] 哈尔滨医科大学第一附属医院心血管内科
关键词
强化降脂; 他汀; 有效性; 安全性; 斑块逆转; 炎症;
D O I
暂无
中图分类号
R54 [心脏、血管(循环系)疾病];
学科分类号
1002 ; 100201 ;
摘要
近年来多项临床试验证实了他汀强化降脂治疗较之常规降脂治疗具有更显著的临床获益,并且强化降脂治疗能够延缓动脉粥样硬化斑块进展,甚至逆转斑块。现综述近年来有关他汀强化降脂更多获益及逆转斑块的证据,并进一步探讨有关"thelower,the better"的结论的临床应用及他汀逆转斑块的相关机制。
引用
收藏
页码:758 / 762
页数:5
相关论文
共 17 条
[11]  
Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis [J] . Vasilios G Athyros,Konstantinos Tziomalos,Thomas D Gossios,Theodora Griva,Panagiotis Anagnostis,Konstantinos Kargiotis,Efstathios D Pagourelias,Eleni Theocharidou,Asterios Karagiannis,Dimitri P Mikhailidis.&nbsp&nbspThe Lancet . 2010
[12]  
Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials [J] . Naveed Sattar,David Preiss,Heather M Murray,Paul Welsh,Brendan M Buckley,Anton JM de Craen,Sreenivasa Rao Kondapally Seshasai,John J McMurray,Dilys J Freeman,J Wouter Jukema,Peter W Macfarlane,Chris J Packard,David J Stott,Rudi G Westendorp,James Shepherd,Barry R Davis,Sara L Pressel,Roberto Marchioli,Rosa Maria Marfisi,Aldo P Maggioni,Luigi Tavazzi,Gianni Tognoni,John Kjekshus,Terje
[13]   Meta-analysis of Comparative Efficacy of Increasing Dose of Atorvastatin Versus Rosuvastatin Versus Simvastatin on Lowering Levels of Atherogenic Lipids (from VOYAGER) [J].
Nicholls, Stephen J. ;
Brandrup-Wognsen, Gunnar ;
Palmer, Mike ;
Barter, Philip J. .
AMERICAN JOURNAL OF CARDIOLOGY, 2010, 105 (01) :69-76
[14]   Efficacy and safety of rosuvastatin in Taiwanese patients [J].
Chiang, Chern-En ;
Huang, Shao-Sung ;
Sung, Shih-Hsieri .
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION, 2008, 71 (03) :113-118
[15]  
Primary prevention of cardiovascular disease with pravastatin in Japan (MEGA Study): a prospective randomised controlled trial [J] . Haruo Nakamura,Kikuo Arakawa,Hiroshige Itakura,Akira Kitabatake,Yoshio Goto,Takayoshi Toyota,Noriaki Nakaya,Shoji Nishimoto,Masaharu Muranaka,Akira Yamamoto,Kyoichi Mizuno,Yasuo Ohashi.&nbsp&nbspThe Lancet . 2006 (9542)
[16]  
Atherosclerotic plaque regres-sion:fact or fiction .2 Shanmugam N,Román-Rego A,Ong P,et al. Cardiovasc Drugs Ther . 2010
[17]  
Effect of two intensivestatinregimensonprogressionofcoronarydisease .2 Nicholls SJ,Ballantyne CM,Barter PJ,et al. NEnglJMed . 2011