Stat5及JAK-Stat5通路

被引：22

作者：

杨磊 ^{[1
,2
]}

韩曜平 ^{[1
]}

顾志良 ^{[1
]}

机构：

[1] 常熟理工学院生物与食品工程学院

[2] 苏州大学基础医学与生命科学学院

来源：

生命科学 | 2012年 / 24卷 / 07期

关键词：

Stat5; 信号通路; 磷酸化; 反馈抑制;

D O I：

10.13376/j.cbls/2012.07.013

中图分类号：

R363 [病理生理学];

学科分类号：

100103 [病原生物学];

摘要：

信号转导与转录因子(Stats)家族是一个由7个成员组成的转录调控家族,其中Stat5由于在多种细胞因子刺激时均可起到重要作用而引起了广泛的关注。Stat5具有两种不同类型,即Stat5a和Stat5b,它们均可被多种细胞因子所激活,启动JAK-Stat5信号通路,从而调节相应基因的表达。在两种Stat5的激活中,特殊位点的丝氨酸和酪氨酸的磷酸化对Stat5的激活起重要的作用。对信号通路严格的控制对于生物体来说具有重要的意义,在JAK-Stat5信号通路中,以SOCS3为代表的SOCS家族对JAK-Stat5的负反馈调节具有重要作用。

引用

页码：680 / 685

页数：6

共 8 条

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