Single nucleotide polymorphism in the STAT5b gene is associated with body weight and reproductive traits of the Jinghai Yellow chicken

被引：20

作者：

Zhao, X. H. ^{[1
,2
]}

Wang, J. Y. ^{[1
,2
]}

Zhang, G. X. ^{[1
,2
]}

Wei, Y. ^{[1
,2
]}

Gu, Y. P. ^{[3
]}

Yu, Y. B. ^{[3
]}

机构：

[1] Yangzhou Univ, Coll Anim Sci & Technol, Yangzhou 225009, Peoples R China

[2] Key Lab Anim Genet Breeding Reprod & Mol Design J, Yangzhou 225009, Peoples R China

[3] Jiangsu Jinghai Poultry Grp Co Ltd, Nantong 226103, Peoples R China

来源：

MOLECULAR BIOLOGY REPORTS | 2012年 / 39卷 / 04期

关键词：

Jinghai Yellow chicken; STAT5b gene; Polymorphism; Haplotype; Body weight traits; Reproductive traits; I GENE; GROWTH; PROLACTIN; FAMILY;

D O I：

10.1007/s11033-011-1202-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

In our research, signal transducer and activator of transcription 5b (STAT5b) gene was studied as candidate gene associated with body weight and reproductive traits of Jinghai Yellow chicken. Single nucleotide polymorphisms (SNPs) of STAT5b gene were examined in both Jinghai Yellow chicken and three reference chicken populations including the Bian, Youxi and Arbor Acre chickens. Two SNPs (C-1591T and G-250A) were detected in the 5' flanking region of STAT5b gene. Association indicated that the C-1591T mutation is significantly associated with age at fist egg, The G-250A mutation is significantly related with hatch weight and body weight at 300 days. Additionally four STAT5b haplotypes (H1, CG; H2, TG; H3, AC and H4, TA) and their frequency distributions were estimated using the phase program. Diplotype H3H4 is dominant for 8, 16 week-age-weight and body weight at first egg. Thus STAT5b gene may be served as a potential genetic marker for growth and reproduction traits evaluation of the Jinghai Yellow chicken. This study will provide valuable information for the protection and breeding of Jinghai Yellow chicken.

引用

页码：4177 / 4183

页数：7

共 24 条

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