骨保护素的研究进展

被引：6

作者：

张海龙

黄朝梁

机构：

[1] 重庆医科大学第二附属医院骨科

来源：

中华医学杂志 | 2006年 / 31期

关键词：

OPG; 骨代谢; RANKL; 破骨细胞; 骨保护素; 骨质疏松; 骨髓基质细胞; 基质(细胞); 类风湿性关节炎; 类风湿关节炎; PTH; mRNA; 分化成熟; 骨髓瘤细胞; 成骨细胞;

D O I：

暂无

中图分类号：

R341 [];

学科分类号：

1001 ;

摘要：

<正>1997年,Simonet等发现一种能够调节骨代谢的糖蛋白,将其命名为骨保护素(osteoprotegerin,OPG)。它与细胞核因子κB受体活化因子配基(receptor activator of nuclear factor kappa B ligand,RANKL)、细胞核因子κB受体活化因子(receptor activator of nuclear factor kappa B,RANK)组成的OPG／RANK／RANKL系统使人们对骨质疏松等疾病的发病机理有了更深入的认识。OPG与骨代谢、心血管系统、免疫系统等都有着重要联系,在类风湿性关节炎、骨髓瘤、冠心病等多种疾病中都发现OPG mRNA水平的异常。OPG的作用主要通过OPG／RANK／RANKL系统来实现,它的临床应用会给这些系统的相关疾病的诊治带来新的突破。

引用

页码：2227 / 2230

页数：4

共 37 条

[1]

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Simonet WS,Lacey DL,Dunatan CR, et al. Cell . 1997

[2]

Cross-talk between the interleukin-6 and prostaglandin E (2) signaling systems results in enhancement of osteoclastogenesis through effects on the osteoprotegerin/receptor activator of nuclear factor-{ kappa } B (RANK) ligand/RANK system. Liu XH,Kirschenbaum A,Yao S, et al. Endocrinology . 2005

[3]

Estrogen specifically stimulates expression and production of osteoprotegerin from rheumatoid synovial fibroblasts. Mitani M,Miura Y,Saura R, et al. Int J Mol Med . 2005

[4]

Osteoprotegerin expression and secretion regulated by calcium influx through the L-type voltage- sensitive calcium channel. Bergh JJ,Xu Y,Farach-Carson MC. Endocrinology . 2004

[5]

Osteoprotegerin mRNA is increased by interleukin-1 alpha in the human osteosareoma cell line MC-63 and in human osteoblast-like cells. Vidal ON,Sjogren K,Eriksson BI,et al. Biochem Biophys Res Commun . 1998

[6]

Osteoprotegerin and receptor activator of nuclear factor-kappaB ligand mRNA expression in patients with rheumatoid arthritis and healthy controls. Vanderborght A,Linsen L,Thewissen M, et al. J Rheumatol . 2004

[7]

Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemical reorganization of the spinal cord. Honore P,Luger NM,Sabino MAC, et al. Nat Med . 2000

[8]

Serum osteoprotegerin levels are associated with the presence and severity of coronary artery disease. Shuichi J,Yuji I,Atsushi S,et al. Circulation . 2002

[9]

Nitric oxide regulates receptor activator of nuclear, factor- kappaB ligand and osteoprotegerin expression in bone marrow stromal cells. Fan X,Roy E,Zhu L,et al. Endocrinology . 2004

[10]

17β-Estradiol stimulates expression of osteoprotegerin by a mouse stromal cell line, ST-2, via estrogen receptor-α. Saika M,Inoue D,Kido S,et al. Endocrinology . 2001

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