骨保护素的研究进展

被引：6

作者：

张海龙

黄朝梁

机构：

[1] 重庆医科大学第二附属医院骨科

来源：

中华医学杂志 | 2006年 / 31期

关键词：

OPG; 骨代谢; RANKL; 破骨细胞; 骨保护素; 骨质疏松; 骨髓基质细胞; 基质(细胞); 类风湿性关节炎; 类风湿关节炎; PTH; mRNA; 分化成熟; 骨髓瘤细胞; 成骨细胞;

D O I：

暂无

中图分类号：

R341 [];

学科分类号：

1001 ;

摘要：

<正>1997年,Simonet等发现一种能够调节骨代谢的糖蛋白,将其命名为骨保护素(osteoprotegerin,OPG)。它与细胞核因子κB受体活化因子配基(receptor activator of nuclear factor kappa B ligand,RANKL)、细胞核因子κB受体活化因子(receptor activator of nuclear factor kappa B,RANK)组成的OPG／RANK／RANKL系统使人们对骨质疏松等疾病的发病机理有了更深入的认识。OPG与骨代谢、心血管系统、免疫系统等都有着重要联系,在类风湿性关节炎、骨髓瘤、冠心病等多种疾病中都发现OPG mRNA水平的异常。OPG的作用主要通过OPG／RANK／RANKL系统来实现,它的临床应用会给这些系统的相关疾病的诊治带来新的突破。

引用

页码：2227 / 2230

页数：4

共 37 条

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